Development Flashcards
What does the standard deviation measure?
A measure of variability
What is a z score?
A number of sd from the mean
How far apart are centile lines placed?
2/3 of a standard deviation apart
A child shows normal growth if what?
- their measurements are within the normal range compared with children of their age
- their rate of growth is within the normal range compared with children of their age
How should children be weighed?
- babies should be weighed without any clothes or nappy
- children older than two years can be weighed in vest and pants, but no shoes, footwear, dolls or teddies in hand
- only class 3 clinical electronic scales in metric setting should be used
How should head circumference be measured?
- measured using a narrow plastic or disposable paper tape
- measurement should be taken where the head circumference is the widest
How should height be measured?
- height should be measured from ages 2 years using a rigid rule with T piece, or stadiometer
- ensure heels, bottom, back and head are touching the apparatus with eyes and ears at 90 degrees
- dont try to stretch up, measure on expiration
What is the average age for a girl to enter puberty?
Average age for girls is 11 years, boys 6 months later on average
What are the gonadotrophins?
FSH and LH
What is precocious puberty?
True central precocious puberty (TCCP) is normal pubertal development occuring abnormally early; <8 years for girls, <9 years for boys. Girls more likely than boys
When is puberty delayed?
Pubertal delay is the absence of secondary sexual development in a girl aged 13 or a boy aged 14 years. Boys more likely than girls
What is the average height difference between adult males and females?
- 5-12cm due to;
- boys have delayed PHV
- boys PHV > girls
- boys taller in pre-puberty
What is the signs of onset in puberty in boys and girls?
- girls = breast development
- boys = testicular volume increase
What system is used to stage puberty?
Tanner chart
Name the different classifications of short stature
- genetic short stature
- constitutional growth delay
- dysmorphic syndromes
- endocrine disorders
- chronic diseases
- psychosocial deprivation
Define adolescence, youth and young people
- adolescence = 10-19 years
- youth = 15-24 years
- young people 10-24 years
How does the brain change in early, middle and late adolescence?
- early; rapid increase in white mater
- middle; increase in myelination, improves decision making
- late; pruning of synaptic connections, further improves decision making, rationalising and judgement
A competent young person should be able to what?
- understand simple terms and the nature, purpose and necessity for proposed treatment
- understand the benefits, risks and effects of, as well as the alternatives to, non-treatment
- understand that the information applies to them
- retain the information long enough to make a choice
- make a choice free from pressure
Name the components of the HEEADSSS framework of things to discuss with young people
H - home (home life / relationships) E - education / employment E - eating, weight, body image A - activities D - drugs S - sex S - suicidality S - safety (risk taking behaviour / criminality)
Describe the basic embryology of the embryonic period
- starts after conception and continues until gestational week 8
- 2 layered embryo
- epiblast and hypoblast
- primitive streak and primitive node
- migration of cells through streak the rostral-caudal migration
- determined by nodal signalling
The ectoderm goes on to create what?
- skin
- nails
- hair
- neural tissue
The mesoderm goes on to form what?
- muscle
- bone
- cartilage
- vascular system
The endoderm goes on to form what?
- gut
- respiratory system
Describe the neural tube
- first well defined neural structure to from
- occurs at day 20-27
- neural progenitor cells form the neural plate
- neural groove
- neural tube formation
The anterior / rostral tube will become what?
The brain
The caudal tube will become what?
The spinal cord
The hollow centre of the neural tube will become what?
The ventricular system and central channel of the spinal cord
The neural progenitor cells line what?
Lune the inside of the neural tube - termed the ventricular zone
Describe neocortical patterning
- the mature neocortex has distinct functional and structural areas
- signalling molecules; Emx2 and Pax6
- high conc Pax6 with low conc Emx2 induce progenitor cells to differentiate into motor neurones
- low conc Pax6 and high conc Emx2 induce visual cortical neurones
What happens to the neurological system during the foetal period?
- development of the gyri and sulci required to accommodate the proliferating neuronal populations
- neuronal progenitor cells in the ventricular zone divide initially ‘symmetrically’ (days 25-42)
- asymmetrical cell division then follows
Describe the development of the sulci
- brain is initially smooth in contour (lisencephalic)
- week 8-26; primary sulci eg longitudinal fissue, sylvian, cingulate, parieto-occipital and calcarine, temporal etc
- secondary sulci weeks 30-35
- tertiary sulci weeks 36 and into post natal period and early infancy
How can neuronal migration occur?
- somal translocation
- radial glial guides
- transgenital migration and signalling pathways
- orderly 6 layered structure with an ‘inside-out arrangement of migrated neurones’
Describe the function of axons
- transmit signals from neurons
- guidance molecules determine their path
- synapses develop when connected with another neuron
Describe the function of dendrites
- gather info and transmit to neurons
- multiple dendrites form ‘arbours’ around the neuron