Development Flashcards
What are the primitive reflexes?
Moro, grasp, rooting, stepping, asymmetrical tonic neck reflex
What are the postural reflexes?
Labyrinthine righting, postural support, lateral propping, parachute
What are the three types of cerebral palsy in order of how common they are?
Spastic, dyskinetic, ataxic
What causes a concomitant squint?
Refractive error
What causes a divergent squint?
Paralysis of the motor nerves
Lifetime prevalence of anorexia nervosa
1% females, <0.5% males
Lifetime prevalence of bulimia nervosa
2% females, 0.5% males
Lifetime prevalence of binge eating disorder
3.5% females, 2% males
Risk factors for eating disorders
Exposure to ideally thin body image Rapid weight loss due to dieting FH of eating disorder, mental health issues Obsessional, perfectionist personality Comorbid mental health issue Certain sports e.g. ballet
What is superior mesenteric artery syndrome?
Seen in referring, due to compression of the SMA as it is no longer protected by a fat pad. Presents with abdominal pain, feeling of fullness, vomiting
What is the global prevalence of ADHD?
5% of children, 2.5% adults
Risk factors for ADHD?
Parental ADHD
Maternal cigarette and alcohol use during pregnancy
Low birthweight
What are the diagnostic criteria for ADHD?
Inattention Hyperactivity and impulsivity Present before 12y Impairs functioning Present in at least 2 settings Not explained by another disorder
What are the 2 main medications used in ADHD?
Dexamphetamine or methylphenidate
What is the mechanisms of action of dexamphetamine and methylphenidate?
Increase extracellular synaptic dopamine
Side effects of stimulant use in ADHD?
Anorexia, weight loss, insomnia, social and emotional withdrawal, priapism, emotional lability, occasional psychosis
What can be used instead of stimulants in ADHD if the parents want a non-stimulant medication?
Atomoxetine
What is the mechanism of action of atomoxetine?
Highly selective inhibitor of the presynaptic noradrenaline transporter - increases extracellular noradrenaline and dopamine levels in the prefrontal cortex
When is clonidine useful in ADHD?
Where there is comorbid tic disorder
What is the mechanism of action of clonidine?
Alpha-2 noradrenergic agonist
What are the side effects of clonidine?
Drowsiness, cardiotoxicity, depression, confusion, dry mouth
Where is melatonin produced?
The pineal gland
What is the heritability of autism spectrum disorder?
50%
What is the recurrence rate in subsequent siblings of a child with autism spectrum disorder?
10-20%
What are the diagnostic criteria for autism spectrum disorder?
Impaired social communication Restricted, repetitive behaviours Onset in early childhood Impairs functioning Not explained by another disorder
Which conditions are associated with autism spectrum disorder?
Rett, fragile X, tuberous sclerosis, Angelman, Down
Which medications might be useful in autism spectrum disorder?
Stimulants
SSRIs - for compulsive/ritualistic behaviours
Melatonin
Atypical antipsychotics e.g. risperidone for aggression
How is Rett syndrome inherited?
X-linked dominant but sporadic in 99% of cases
What is the mutation in Rett syndrome?
Almost always MECP2
What are the features of Rett syndrome?
Developmental regression Dyspraxic gait Stereotypical hand movements Seizures Breathing problems Abnormal tone Screaming or laughing spells Scoliosis Autonomic dysfunction GI problems
What is Rolando variant Rett syndrome?
Congenital where development is impaired earlier