Describe the different components of the peripheral nervous system and how electrical impulses are transmitted. Flashcards

1
Q

Give an overview of the nervous system?

A
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2
Q

Describe the features of cell body (2), dendrites (1), axon (2), nodes of ranvier (2)?

A
  • Cell body:
    • Contains nucleus
    • Proteins produced here
  • Dendrites:
    • Towards cells body (receives and processes)
  • Axon:
    • Away from cell body
    • Arises at axon hillock
  • Nodes of Ranvier:
    • Unmyleinated areas between myelinated areas
    • APs to ‘jump’ node to node = saltatory conduction
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3
Q

What is a motor unit?

A
  • 1 axon and all the muscle fibres it supplies
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4
Q

What is the PNS? and what does does it consist of

A
  • Connection - CNS and body
  1. Peripheral nerves (cranial and spinal)
  2. Motor and sensory neurones
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5
Q

The PNS and two components:

A
  1. Sensory (afferent) division
  • Sensory neurones
  • Receptors to CNS
  1. Motor (efferent) division
  • Motor neurones
  • CNS to effectors
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6
Q

The motor division has two components:

A
  1. Somatic Nervous System:
    * Controls vascular movements
  2. Autonomic Nervous System:
    * Controls involuntary responses e.g. heart rate
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7
Q

The autonomic nervous system has two components which work…. and why?

A
  • Antagonistically
  • Maintenance of homeostasis
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8
Q

The autonomic nervous system has two components

A
  • Sympathetic
    • Mobilises body systems
    • Flight or fight
  • Parasympathetic
    • Conserves energy
    • Rest and digest
    • Controls simple involuntary reflexes
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9
Q

Give the 4 steps involved in the flight or fight response:

A
  1. Stressor –> amygdala activated –> impulses to hypothalamus
  2. ANS switches from PNS to SNS –> impulses to adrenal medulla = adrenaline and noraadrenlaine
  3. Hormone = physioloigcal changes
  4. Threat passsed - SNS to PNS
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10
Q

Give 6 examples of complementary phsyiological chances during a sympathetic and parasympathetic state:

A
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11
Q
  • What is the resting potential
  • What is the main reason the resting potential occurs? (3)
  • How is the membrane potential maintained?
A
  • -70 mV
  • Ions are unevenly distributed
    • More permemable to K+ than Na+
    • More negative inside than out = more +ve ions flow out than in
  • Na+/K+ pump (3 Na+ out for every 2K+ in)
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12
Q

Define the term action potential?

A
  • A transient depolarisation triggered by a depolarisation beyond a threshold
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13
Q

D

A
  1. Resting potential (-70 mV)
  2. Electrical stimulus = voltage gated Na+ channels open
  3. Threshold (-55 mV) reached = more voltage gated Na+ channels open
  4. At +40 mV = voltage gated Na+ channels close and voltage gated K+ channels open.
  5. Repolarisation - K+ move down their electrochemical gradient
  6. Hyperpolrisation - Membrane potential overshoots
  7. Relative refractory period
  8. Resting membrane potential = Na+/K+ pump
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14
Q

Explain the propagation of action potential in an unmyelianted axon?

A
  • AP is propagated along the entire length of the axon
    • More voltage-gated Na+ channels are opened as depolarisation spreads.
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15
Q

Speed of conduction depends on 3 main factors:

A
  • Myelin sheath:
    • Electrical insulator
    • AP jump node to node via saltatory conduction
  • Diameter of Axon:
    • Larger diamter = faster speed of conductance = less leakage of ions
  • Temperature:
    • Higher temp = faster speed of conductance = enzymes work faster
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16
Q

What is axoplasmic transport and where does it occur?

A
  • Movement of synaptic vesicles to/from cell body
  • Axoplasm
17
Q

What is anterograde and name the motor protein responsbile?

A
  • Away from cell body
  • Kinesin
18
Q

What is retrograde transport?

A
  • Towards cell body
  • Dynein
19
Q

Give the 7 steps involved in transmission of chemical synapses

A
  1. Neurotransmitter molecules are synthesised and packaged in vesicles
  2. Action potential arrives - pre synaptic terminal
  3. Volagte gated Ca2+ channels open
  4. Synaptic vesicles fuses with presynnaptic membrane
  5. NT molecules diffuse acorss cleft and bind to specfic receptors on postsynaptic cell
  6. Bound receptors activate postsynaptic cell
  7. Neurotransmitter breaks down, taken up by presynaptic cell or other cell or diffuses away from synapse.