Derniers cours Flashcards by Thomas Jestin

Q

2 cardiomyocytes

A

99% contractiles
1% auto

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Q

potentiel membrane auto

A

-60mV

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Q

potentiel membrane contractile

A

-90mV

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Q

canaux Kv

A

tétramère 6STM

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Q

canaux Nav et Cav

A

monomérique 4domaines 6STM

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Q

canaux Kir

A

tétramère 4sous unités 2 TM

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Q

pore segment

A

S5 S6

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Q

pore vitesse passage d’ions

A

10^7/s

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Q

voltage sensor segment

A

S4

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Q

gène Nav1.5

A

SCN5A

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Q

gène Cav1.2

A

CACNA1C

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Q

échangeur NCX

A

normal mode:
3Na+ in
1Ca2+ out

reverse mode:
3Na+ out
1Ca2+ in

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Q

voltage ouverture canaux if

A

en dessous de 40mV

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Q

voltage ouverture canaux sodique cardiaque

A

-70mV

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Q

voltage ouverture canaux calcique CavL cardiaque

A

-40mV

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Q

phases cell auto

A

4 DDSL from -60 to -40 mV, flow in of Na+

0 flow in of Ca2+

3 flow out of K+ through potassium channel ,and Na+/K atp ase

Q

phases cell contractile

A

0PA from -90 to -70

canaux sodiques from -70 to +30

1 flow out of K+

2 under -40mV, activation of calcium channel flow in of Ca2+

also flow in of Na+ through the NCX

3 kv out
4 stable -90 Na/k atp ase

Q

période réfractaire absolue cell contr coeur

A

2-3

Q

période réfractaire relative cell contr coeur

A

fin phase 3

Q

taille cardiomyocytes

A

50-100microm

Q

taille sarcomère cardiaque

A

1.8-2.2microm

Q

la tropomyosine se trouve à raison de

A

7 perles d’actine

Q

connexon cmb de connexine

A

6 ici mais dans les autres 12

Q

calséquestrine cmb de Ca2+

A

50

Q

concentration calcique libre repos

A

100nM

Q

concentration calcique libre excité

A

1microm

Q

augmentation de la concentration calcique comment

A

10% Canaux calciques
90% RS

Q

relaxation wie

A

90% SERCA
10% échangeur NCX

Q

Quand se ferme NA

A

J26

Q

Quand se ferme NP

A

28/29j

Q

Membrana reuniens

A

Somatopleur + mesoblaste