Dermatology

Question 1

Two Calcineurin Inhibitors

Answer 1

Pimecrolimus and Tacrolimus

Question 2

Mechanism of action of Pimecrolimus

Answer 2

release of inflammatory cytokines and inflammatory mediators from mast cells. Mild to moderate atopic dermatitis

Question 3

Mechanism of action of tacrolimus

Answer 3

• Inhibits t-cells, mast cells, langerhan cells, kerocytes (tacrolimus)
• Moderate to severe atopic dermatitis

Question 4

True or false. Calcineurin inhibitors can be used in all areas of the body

Answer 4

True. Best for maintenance. Comparable to mid potency corticosteroids.

Question 5

Tacrolimus peds dosing (ages 2-15)

Answer 5

0.03%

Question 6

Tacrolimus adult dosing

Answer 6

0.1% (never use 0.03%)

Question 7

Pimecrolimus dosing

Answer 7

1%

Question 8

3 point treatment regimen for atopic dermatitis

Answer 8

1st: hydration. Daily showers
2nd: Steroid (cortisone) within 3 minutes
3rd: emollient: Rub cream/lotion over cortisone to seal it in

Question 9

Mechanism of action for topical corticosteroids

Answer 9

• Suppress release of cytokines
• Inhibit migration of macrophages and leukocytes by reducing vascular dilation and permeability thus decreasing edema, erythema, itching

Question 10

Children younger than 12 should not be treated with this group of topical corticosteroids

Answer 10

Group 1 and 2

Question 11

Potency of topical steroids is determined by this:

Answer 11

By vasoconstrictor assays (not strength of steroid)

Question 12

List type of vehicles from best to worst

Answer 12

ointments, creams, solutions and lotions

Question 13

Absorption is enhanced by:

Answer 13

Skin temperature, hydration, thin stratum corneum, occlusive dressing, infant/children, denuded, hydration

Question 14

Clobetasol cream/ointment/solution

Answer 14

High potency topical corticosteroid. Used for psoriasis and stubborn dermatitis

Question 15

Desoximetasone

Answer 15

High potency topical corticosteroid for hyperkeratotic dermatitis

Question 16

Triamcinolone 0.1% ointment or cream

Answer 16

Mid potency topical corticosteroid for Eczematous dermatitis.

Question 17

Hydrocortisone

Answer 17

Low potency topical corticosteroid.

Question 18

True or false: Do not occlude calcineurin inhibitors

Answer 18

True

Question 19

After how long should you change treatment if you are not noticing change when treating with calcineurin inhibitors

Answer 19

2-3 weeks

Question 20

How does Eurisa work?

Answer 20

Inhibits PD4 and increases cAMP levels.

• Mild-moderate AD
• ages 2 and older
• may be used on all body areas

Question 21

Dupixent works as a

Answer 21

Interleukin inhibitor. Inhibits the inflammatory response

Question 22

How can antipruretics help AD?

Answer 22

Break the itch-scratch-itch cycle.

*May use benedryl, atarax(nighttime), or gabapentin

Question 23

Doxepin cream can be used as a?

Answer 23

Topical antipruretic

Question 24

Primary tx for genital herpes

Answer 24

acyclovir 1 g BID 7-10

Question 25

Recurrent genital herpes treatment

Answer 25

2 gram BID once

Question 26

Treatment for herpes zoster

Answer 26

1 g TID 7 days

Question 27

Treatment for mulluscom contagiosum

Answer 27

Infants and children: wait for natural immunity

Adults: curettage, liquid nitrogen, cantharidin

Question 28

Treatment for measles

Answer 28

Vitamin A can reduce morbidity and mortality

Question 29

Impetigo is caused by ___

Answer 29

Staph infection

Question 30

Impetigo can be treated with

Answer 30

Mupirocin ointment or if extensive, cephalexin or clindamycin

Question 31

Tinea infections can be treated with

Answer 31

terbinofine