Dermatological Flashcards

1
Q

Clark level I

A

Confined to epidermis

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2
Q

Clark level II

A

Invasion of papillary dermis

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3
Q

Clark level III

A

Filling of papillary dermis but not extending into reticular dermis

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4
Q

Clark level IV

A

Invasion of reticular dermis

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5
Q

Clark level V

A

Invasion of deep subcutaneous tissue

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6
Q

Breslow’s depth I

A

≥0.75 mm

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7
Q

Breslow’s depth II

A

0.76-1.5 mm

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8
Q

Breslow’s depth III

A

1.51-2.25 mm

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9
Q

Breslow’s depth IV

A

2.26-3 mm

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10
Q

Breslow’s depth V

A

> 3 mm

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11
Q

Basal cell carcinoma appearance

A
  • Pearly white papule/plaque
  • Overlying telangiectasiae
  • Central ulceration
  • Raised, rolled border
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12
Q

Management of basal cell carcinoma

A
  • Electrodessication and curettage
  • Cryotherapy
  • Topical therapy (e.g. fluorouracil)
  • Full thickness excisional biopsy
  • Mohs surgery
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13
Q

Modified BRE grading

A

Tubule formation
Nuclear pleomorphism
Mitotic count

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14
Q

Types of melanoma

A
  • Superficial spreading (on women’s legs and men’s torsos, age 30-50)
  • Nodular
  • Lentigo maligna (on sun-damaged face, elderly)
  • Acral lentignous (on palmar/plantar skin, in darker people)
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15
Q

Squamous cell carcinoma appearance

A
  • Red papule/plaque
  • May become nodular with warty surface
  • Central necrosis and sloughing to become ulcer
  • Bleeding
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16
Q

Immunopathology of pemphigus vulgaris

A

Anti-desmosome IgG antibodies (between keratinocytes)

17
Q

Immunopathology of bullous pemphigoid

A

Anti-hemidesmosome IgG antibodies (between epidermis and dermis)

18
Q

Clinical features of pemphigus vulgaris

A
  • Superficial, painful lesions
  • Mouth erosions
  • Epistaxis
  • Dysphagia/odynophagia
  • Conjunctivitis
  • Nikolsky’s sign
19
Q

Clinical features of bullous pemphigoid

A

Deeper, pruritic lesions

20
Q

Breast cancer screening

A
  • Women aged 50-74 invited for mammogram every 2 years

- Women aged 40-49 and 75+ can also participate