Derma lectures Flashcards

1
Q

Tuber=

A

Cellular infiltration in the reticular dermis and SC

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2
Q

Gumma is a type of

A

Tuber

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3
Q

Urticaria=

A

Edema of the dermis

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4
Q

Etiology of lower limb ulcers

A
Venous insuff.
Arterial insuff.- PAD
Neuropathy
Microcirculation abnormalities
Vasculopathy
Vasculitis
Pyoderma gangrenosun
Tumor
Injury
Infection
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5
Q

Inflammation of the layer of fat under the skin=

A

Panniculitis

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6
Q
Leg looks like this-
Livid brown color
Atrophy
Scarring
Loss of hair

What is it called?

A

Lipodermatosclerosis

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7
Q

Venous ulcer location and properties

A

Mainly above inner/outer ankle
Moderate pain
Not deep
Irregular shape

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8
Q

Artrial ulcer location and properties

A

Sharply demarcated
Ring shape
Tose are not affected
Very painfull

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9
Q

Pyoderma gangrenosum- describe the ulcer

A
Painful
Devrlops rapidly
Purple
Pustules
Ulcers
Mainlly on shins
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10
Q

Treatment for acne vulgaris

A
Benzoyl peroxide
Retinoids
Tretinoin gel
Azelaic acid
Erythromycin
Oral isotretinoin
Anti adronergic drugs- Spironolactone
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11
Q

Rosacea=

A

Chronic inflammatory skin disease in the central face with flushing erythema telangiectasia, papules and pustules

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12
Q

Rosacea treatment

A

Metronidazole
Low dose Doxyxycline
Azelaic acid
Isotretinoin

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13
Q

Lichen Planus etiology

A

Unknown
Possible autoimune (Ab against desmoglein 3/ collagen VII
Associated with Hep. C
Stress

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14
Q

Lichen Planus- how does it look like?

A
Pruritic
Purple
Papule
Polygonal
Wickham's striae
Nail distrophy
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15
Q

NGU

לפרטנרים מלפני כמה זמן צריך לעדכן

A

2 months

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16
Q

Syphilis

לפרטנרים מלפני כמה זמן צריך לעדכן

A

Primary- 3 months
Secondary- 6 months
Early latent- 12 months

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17
Q

Vaginal pH

A

3.8-4.7

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18
Q

Syphilis most common non specific test

A

RPR

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19
Q

Syphilis most common specific test

A

TPPA

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20
Q

We give in case of Syphilis what I.M?

How much in primary?

A

Benzatene Penicillin

2.4 million I.U

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21
Q

Atypical course of Lymphogranuloma venarum

A

Intraanal entry -> Purulent proctitis (looks like IBD) -> Strictures and pistula

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22
Q

Lymphogranuloma venarum treatment

A

Doxycycline 2X100 mg for 21 days

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23
Q

HPV incubation period

A

6-12 months

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24
Q

Which virus doesnt have a specific therapy?

A

HPV

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25
Q

Lyme disease general treatment

A

Doxyxycline 100 mg X 2 per day for 10-21 days

Cefuroxime 500 mg X 2 per day for 10-21 days

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26
Q

Folliculitis Furuncle Carbucle treatment

A

Fuzidic acid
Penicillin
Cephalosporin

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27
Q

Impetigo local treatment

A

Mupirocin oinment
Fusidin acid oinment
Betadine

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28
Q

Erysiples treatment

A

Systemic aminopenicillin
Cephalosporines

Clindamycin
Ciprofloxacin

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29
Q

Herpes zoster treatment

A

Systemic acyclovir 5X800 mg

Painkillers

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30
Q

Scabies treatment

A

Benzoyl benzoat
Permethrin leave on for 12 h
Ivermectin

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31
Q

Classifications of Cutan lupus erythematus

A

Acute
Sub acute
Chronic

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32
Q

What is always present in case of Cutan lupus erythematus

A

Photosensitivity

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33
Q

Which Cutan lupus erythematus is always a part of SLE?

A

Acute CLE

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34
Q

Genetic factors affecting CLE

A

MHC complex and comlement cascade

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35
Q

Enviormental factors affecting CLE

A
UV
Smoking
Cold
Female hormones
Drugs
Infections
Stress
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36
Q

Which Ab are present in CLE?

A
ANA
SSA
SSB
Anti-dsDNA
C1q AB
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37
Q

Acute CLE symp.

A

Butterfly erythema

Photosensitivw lupus dermatitis

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38
Q

Subacute CLE symp.

A

Annular

Papulosquamous/psoriasiform

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39
Q

Annular form in SCLE describe it

A

Erythematous
Central atrophy
Scaly plaques

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40
Q

SCLE treatment

A

Avoid sun
Local cortico.
Chloroquine/Hydroxycloroquine
Systemic cortico.

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41
Q

Chronic CLE can be divided into

A

Localized discoid
Generalised discoid
Hypertrophic
Tumidos

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42
Q

What is the most fequent form of CCLE?

A

Discoid LE

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43
Q

Discoid LE skin symp.

A
Erythematous
Telangiectasia
Plaques covered with hyperkeratosis
Scar formation
Scarring alopecia
44
Q

Sprcial feature of Discoid LE

A

Scarring alopecia

45
Q

LE therapy

A
UV protection
Vit. D
Quit smoking
Local cortico.
Antimalarial drugs
Azathioprin
Methotrexate
Biologic therapy
46
Q

Biologic therapy for LE

A

Belimumab

47
Q

What is the most frequent form of CLE?

A

Discoid

48
Q

SCLE clinically can be two forms-

A

Annular

Psoriasiform

49
Q

How does SCLE regress?

A

Vitiligo like hypopigmented mucules

50
Q

Localized scleroderma=

A

Morphea

51
Q

Two phases of localized scleroderma

A

Initial inflammatory

Late fibrotic

52
Q

Localized scleroderma Limited types (3)

A

Plaque morphea
Guttate morphea
Suprficial morphea

53
Q

Generalized morphea definition

A

4 or more plaques of more than 3 cm involving 2 ore more anatomical regions

54
Q

Which scleroderma is common in kids?

A

Linear

55
Q

Localized scleroderma treatment

Limited skin involvement

A

Topical cortico.
Topical calcineurin
PUVA

56
Q

Localized scleroderma treatment

Severe skin involvement

A

MTX 12 months
Methylprednisone
Prednisolone

57
Q

Localized scleroderma Limited types

Which is most common

A

Plaque type

58
Q

Localized scleroderma Limited types

What is a sign of active inflammation?

A

Lilach ring

59
Q

What can causes the mortality in case of Dermatomyositis?

A

Interstitial Lung Didease

60
Q

Diagnostic criteria for Dermatomyositis

A
Proximal muscle weakness
Positive muscle biopsy
Increased skeletal muscle enzymes
EMG
Cutaneous symp.
61
Q

Dermatomyositis Cutaneous symp.

A
Heliotrop rash
Livid erythema
Scalp involvement
Gottorn papules (MCP)
Gottorn sign (Elbows, knees)
V sign
Periungual sign
Poikiloderma
62
Q

Another type of Dermatomyositis

A

Amyopathic Dermatomyositis

63
Q

Is psoriasis itchy?

A

Not that much

64
Q

Primary and secondary lesions found in Psoriasis

A
Plaque
Patch
Papules
Scaling
Fissures
Rhages
65
Q

Psoriatic skin lesions induced by traume to the skin is also called

A

Koebner phenomenon

66
Q

Psoriasis prelevance

A

1-2% of adults

67
Q

Genetics assoiciated with Psoriasis

A

HLA-B27

68
Q

Medications that can evoke Psoriasis?

A

B Blockers
Lithium
INF-a

69
Q

Psoriasis- where is it usually found on the body?

A
Elbows
Knees
Scalp
Back
Nails
Folds
70
Q

Nails symp. in Psoriasis

A
Beau pitting
Oildrop sign
Onycholysis
Keratosis
Dystrophy
71
Q

Histology findings in Psoriasis

A

Papillomatosis
Acanthosis
Parakeratosis

72
Q

What is Guttate Psoriasis

A

Many smll scaly papules

73
Q

Guttate Psoriasis is often triggered by

A

Strep.

74
Q

Special forms of Psoriasis

A

Erythrodermic
Pustulosa
Inverse
Palmoplantar

75
Q

Scoring systems for Psoriasis

A

PASI (Psoriasis Area Severity Index)

BSA (Body Surface Area)

76
Q

For patient with 90% PASI (Psoriasis Area Severity Index) how will you treat?

A
Methotrexate= Folic acid antagonist
Adalimumab= Anti TNF-a
77
Q

Treatment for Buulous Pemphigoid

A

Methotrexate
Azathioprin
Dapson
Doxyxycline

78
Q

Define Dermatitis herpatiformis

A

Autoimmune bullous disease

79
Q

Auto-Ag in Dermatitis herpatiformis

A

Tranglutaminase 3

80
Q

Describe classic case of BCC

A
Sun exposed skin
Old age
Shiny
Pearly border
Telangiectasia
Ulceration
81
Q

Types of BCC

A

Nodular
Superficial
Pigmented

82
Q

Low risk BCC treatment

A

Surgical excision with 3-5 mm borders

83
Q

High risk BCC treatment

A

MOHS surgery (Microscopically Oriented Histologic Surgery)

84
Q

Non surgery BCC treatment

A

Radiation
Cryotherapy
Laser therapy
Sonidegib

85
Q

How do we classify SCC

A

By differentiation

Well, moderate, poorly

86
Q

In which case will we use radiation in SCC?

A

In situ form, does not invase the BM

87
Q

SCC therapy most likely will be

A

MOHS

88
Q

Which skin cancer do not form on mucos mmb.?

A

BCC

89
Q

Which cancer is in connection with chronic sun exposure?

A

SCC

90
Q

Melanoma classification

A

Superficial spreading
Nodular
Lentigo maligna
Acral lentigoid

91
Q

Therapy for primary melanoma

A

Surgical removal with 5-20 mm border according to Breslow scale

92
Q

Breslow I means

A

Intraepidermal

93
Q

Breslow V means

A

Enters fat

94
Q

Melanoma immunotherapy

A

Nivolumab

Pemprolizumab

95
Q

New therapy for Melanoma?

A

Ipilimumab (Target cytotoxic T cells)

Vemurafenib

96
Q

Psoriasiform hyperplasia=

A

Elongation of rete ridges and elongation of dermal papillae

97
Q

Which WBC are found in Billous pemphigoid and where can we find them?

A

Eosinophils

In the papillary dermis and the blister fluid

98
Q

Dermatitis herpatiformis

What will we see on histology and on IF?

A

Fibrin and neutrophils at the tip of dermal papillae
Small microabscess
IgA type Ab at the tips of dermal papillae

99
Q

Special histological feature of BCC

A

Palisade

100
Q

SCC may arrise from (2 lesions)

A

Keratoacanthoma

Actinic keratosis

101
Q

Common mole is also called

A

Melanocytic nevi

102
Q

Where can we find junctional nevus?

A

Epidermis

103
Q

Where can we find compound nevus?

A

Epidermis and dermis

104
Q

Nevus that is only present in the dermis?

A

Intradermal

105
Q

Dermis can be divided into

A

Papillary dermis
Papillary reticular
Reticular dermis

106
Q

Kaposi sarcoma

A
Purple
Singular/wide spread
Flat/raised
HHV8
Immunosuppression
AIDS
Skin
Mucosal
Internal organs
107
Q

Kaposi sarcoma histology

A

Plump spindled shape stromal cells