Derm Epithelial Tumors Flashcards
75 yo Pt presents with a plaque on her foot that looks like a coin stuck her with waxy appearance. Is this a malignant or benign presentation? What would you see on histology? What would happen if she had more than one of these coins?
She has SEBORRHEIC KERATOSIS. This is a benign squamous proliferation common in the elderly. Characterized by keratin pseudo cysts on histology. If multiple SEBORRHEIC keratosis , she has Leser Trelat sign which is a sudden onset and suggestive of underlying carcinoma of the GI tract.
Pt comes in with complaints of her groin area feeling like velvet and appearing dark in color. What is this disease associated with?
Acanthosis Nigricans associated with insulin resistance or malignancy especially gastric carcinoma.
Pt comes in with an ulceration on the upper lip surrounded by blood vessels. When describing it to you, she mentioned it looks like her grandmother’s pink pearls. What would you see on histology? How would you classify it? What are the risk factors and how would you treat her?
Patient has BASAL CELL CARCINOMA which is a malignancy of the basal cells of the epidermis. Histology shows basal cells with peripheral palisading. Risk factors are UVB, albinism and XP. Tx is surgical extension. Mets are rare.
Pt comes in with an ulceration on the lower lip. When describing it to you, she mentioned it is nodular.How would you classify it? What are the risk factors and how would you treat her?
Patient has Squamous cell carcinoma which is a malignant proliferation of squamous cells characterized by formation of keratin pearls. Risk factors are UVB, albinism and XP. Additional risks are immunosuppressive therapy, arsenic exposure and chronic inflammation e.g scars from burns Tx is surgical extension. Mets are rare.
This is a well differentiated squamous cell carcinoma that develops rapidly and regresses spontaneously. What is it? How else will it present?
Keratoacanthoma which presents as a cup shaped tumor filled with keratin debris.
Pt presents with a scaly plaque on her back and neck that is hyper keratotic. What do he have ?
Actinic keratosis which is a precursor lesion to squamous cell carcinoma
What is the classic location of basal cell carcinoma ? Squamous cell carcinoma?
Basal cell carcinoma is upper lip and squamous cell carcinoma is lower lip. BS.
What are the four layers of the epidermis and their functions?
Stratum basalis - regenerative stem cell layer
Stratum spinosum - characterized by desmosomes between keratinocytes
Stratum granulosum - characterized by granules in keratinocytes
Stratum corneum - characterized by keratin in anucleate cells
What structures are in the dermis?
Connective tissue, nerve endings, blood and lymphatic vessels, and adnexal structures such as hair shafts, sweat glands and sebaceous glands.
