Derm Drugs (Pt II)

Question 1

Topical glucocorticoids have what type of effect and can result in what if used chronically?

Answer 1

anti-inflammatory and immunosuppressive effects; can result in tachyphylaxis

Question 2

MOA of topical glucocorticoids?

Answer 2

alter gene expression by binding to glucocorticoid response elements on DNA

Question 3

which topical glucocorticoid is used for corticosteroid-responsive dermatoses?

Answer 3

hydrocortisone

Question 4

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp, and plaque psoriasis?

Answer 4

Betamethasone

Question 5

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp, and plaque psoriasis >18 y/o?

Answer 5

Halobetasol

Question 6

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses and psoriasis but has an adverse effect of growth retardation in children?

Answer 6

Clobetasol

Question 7

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp and moderate-severe atopic dermatitis in pediatric pts?

Answer 7

Fluocinolone

Question 8

Combo of a topical retinoid w/ what is more efficacious than mono therapy?

Answer 8

antimicrobial

Question 9

Which topical retinoid binds to specific retinoic nuclear receptors, is comedolytic, bactericidal, and normalizes desquamation?

Answer 9

Adapalene

Question 10

Which topical retinoid cannot be used in pregnancy, has anti-inflammatory properties and is more effective when combined with an antimicrobial?

Answer 10

Tretinoin

Question 11

What is a prodrug that is hydrolyzed by an esterase and binds to retinoic receptors to tx acne vulgaris, psoriasis, etc.?

Answer 11

Tazarotene

Question 12

Which topical retinoid is a pregnancy category X?

Answer 12

Tazarotene

Question 13

Which systemic retinoid decreases sebum and is used to tx SCC but is a teratogen?

Answer 13

Isotretinoin

Question 14

Women of childbearing age have to be using 2 forms of contraception and monthly pregnancy test in order to use which drug?

Answer 14

Isotretinoin

Question 15

what affects <10% of body surface area, is caused by drugs and occasionally Mycoplasma?

Answer 15

SJS

Question 16

What affects >30% BSA, potentially fatal, and is due to drugs?

Answer 16

TEN

Question 17

What type of drugs are 1st line for pruritis should be cautioned in the elderly population?

Answer 17

Antihistamines

Question 18

(T/F) Sedating H1 receptor and H2 receptor agonist have at most a limited effect in tx of chronic itch

Answer 18

FALSE- Nonsedating; sedating may be best at night and is better

Question 19

which antihistamine is used for chronic urticaria, drug-related itch and are CI in neonates, premature infants, and nursing moms?

Answer 19

Diphenhydramine

Question 20

which drug blocks H1 and H2 receptors to tx moderate pruritis but cannot be given w/ antidepressants bc it can prolong the QT interval?

Answer 20

Doxepin

Question 21

Black box warning for doxepin?

Answer 21

increases suicidality risk in children- young adults w/ major psych disorders!

Question 22

which oral antihistamine is used to tx histamine mediated pruritis and doesnt mix well w/ sertraline?

Answer 22

Hydroxyzine

Question 23

Which hypo pigmentation agent inhibits tyrosinase and reduces hyperpigmentation (temporary lightening) and can have possible carcinogenicity?

Answer 23

Hydroquinone

Question 24

Which hypopigmentation agent causes irreversible depigmentation and should be restricted to pts w/ widespread vitiligo?

Answer 24

Monobenzone

Question 25

Which hypopigmentation agent is a substrate for the enzyme tyrosinase & is competitive inhibitor of the formation of melanin precursors and used for solar lentigines?

Answer 25

Mequinol

Question 26

Mequinol combined w/ what drug may cause fetal harm?

Answer 26

Tretinoin

Question 27

trichogenic agent used to stimulate hair growth secondary to vasodilation that reverses progressive miniaturization of terminal scalp hairs?

Answer 27

Minoxidil (topical)

Question 28

Which trichogenic agent is 5 alpha reductase inhibitor promotes hair growth and should not be used in pregnant women?

Answer 28

Finasteride (oral)

Question 29

Which trichogenic agent is a synthetic analog of prostaglandin and is used for eyelashes?

Answer 29

Bimatoprost (ophthalmic solution)

Question 30

what is a chronic autoimmune inflammatory disease has a significant genetic and environmental association and IL-12,IL-17, and IL-23?

Answer 30

Psoriasis

Question 31

Which oral psoriasis tx activates retinoid acid receptors to tx severe psoriasis and should NOT be used in pregnancy?

Answer 31

Acitretin

Question 32

Which oral psoriasis tx is a selective inhibitor of PDE4 and inhibits spontaneous production of TNF alpha?

Answer 32

Apremilast

Question 33

Which psoriasis tx binds to vitamin D receptors and inhibits keratinocyte proliferation while enhancing differentiation?

Answer 33

Calcipotriene

Question 34

Which psoriasis tx is better tolerated and is used to tx plaque psoriasis?

Answer 34

Calcitrol

Question 35

Which biologic agent is a decoy receptor?

Answer 35

Etanercept

Question 36

Which biologic agent is a partially humanized mouse antibody against TNF alpha?

Answer 36

Infliximab

Question 37

Which biological agent is a fully human IgG1 antibody?

Answer 37

Adalimumab

Question 38

Which biological agent binds selectively and neutralizes human TNF alpha activity?

Answer 38

Certolizumab

Question 39

Before starting biologics, always check what..?

Answer 39

check PPD to r/o TB

Question 40

Which biologic agent binds w/ high affinity and specificity to the p40 protein subunit used by both IL-12 and IL-23 ?

Answer 40

Ustekinumab

Question 41

Which biological agents bind selectively to the p19 subunit of IL-23?

Answer 41

Guselkumab, Tildrazkizumab, Risankizumab

Question 42

which biological agents are used to bind selectively w/ IL-17A?

Answer 42

Secukinumab and Ixekizumab

Question 43

Which biological agent binds selectively w/ the IL-17A receptor and has a black box warning of suicidal ideation and behavior?

Answer 43

Brodalumab