Derm Drugs

Question 1

which drugs inhibit the 50S subunit, bacteriostatic and is used topically to inhibit P. acne?

Answer 1

erythromycin and clindamycin

Question 2

which drug can cause pseudomembranous colitis if used chronically and w/ systemic absorption and should not be used as monotherapy?

Answer 2

clindamycin

Question 3

Which drug may cause orange staining of the skin and hair if used in combo w/ benzoyl peroxide?

Answer 3

Dapsone

Question 4

which drug releases active free-radical oxygen species, is bactericidal when used w/ antibiotics?

Answer 4

Benzoyl peroxide

Question 5

Which topical drug has anticomedonal effect and is a competitive inhibitor of mitochondrial oxidoreductase and 5-alpha reductase? What does it do?

Answer 5

Azelaic acid; it lightens post-inflammatory hyper pigmentation

Question 6

Which 3 oral drugs reversibly bind to the 16S rRNA of the 30S subunit and prevents binding on aminoacyl tRNA to the acceptor site? (used to tx acne vulgaris)

Answer 6

doxycycline, minocycline, tetracycline

Question 7

What is it called when a dermatophyte infxn penetrates the hair follicle and involves the dermis?

Answer 7

Majocchi granuloma

Question 8

tinea ___ is a nail infxn caused by dermatophytes ONLY

Answer 8

unguinium

Question 9

which topical antifungals inhibit CYP450 14- alpha-demethylase and not useful for onychomycosis?

Answer 9

Clotrimazole & Miconazole

Question 10

Which topical antifungal is used for diaper rashes by candida albicans?

Answer 10

Miconazole

Question 11

Which topical/oral drug can be used for seborrheic dermatitis, white/black piedra, and should NOT be used in pts w/ achlorhydria, on bicarb, antacids, and H2 blockers/PPIs?

Answer 11

Ketoconazole

Question 12

Which oral antifungal can be used for white piedra, onycho-, lobo-, and chromoblasto-,mycosis? This drug has a black box warning that it can cause exacerbation of CHF?

Answer 12

Itraconazole

Question 13

Which oral antifungal is used for onychomycosis as a last resort and can cause rare hepatotoxicity?

Answer 13

Fluconazole

Question 14

Which class of drugs are more effective than topical azole agents against common dermatophytes but less effective when it comes to candida infxns?

Answer 14

Topical and oral allylamines

Question 15

Which allylamine inhibits squalene epoxidase and is first line for dermatophytosis and onychomycosis?

Answer 15

Terbinafine

Question 16

CI and adverse effects of terbinafine?

Answer 16

CI in pts w/ renal or hepatic failure or pregnancy

adverse: change or loss of taste and smell

Question 17

which topical allylamine is anti-inflammatory activity and if fungicidal?

Answer 17

Naftifine

Question 18

Which topical benzylamine cause used for tinea versocolor and tinea nigra?

Answer 18

Butenafine

Question 19

Which oral drug is used for tinea capitis but was replaced by oral terbinafine for tx of onchomycosis? This drug is CI in pregnancy, & pts w/ porphyria & hepatic failure!

Answer 19

Griseofulvin

Question 20

Which drug is thought to be involved w/ chelation of polyvalent cations and used in white piedra, seborrheic dermatitis, and onychomycosis?

Answer 20

Ciclopirox Olamine

Question 21

Which topical antiviral is a TLR7 agonist that induces production of interferons alpha and gamma to used for genital warts and molluscum contagiosum?

Answer 21

Imiquimod

Question 22

(peds drug) Which oral antiviral is an H2 antagonist and is used to tx warts and molluscum contagiosum in children?

Answer 22

Cimetidine

Question 23

(T/F) there is no gold standard or FDA approved for molluscum contagiosum

Answer 23

TRUE

Question 24

Mucocutaneous herpes infxn is tx systemically by which 2 drugs that inhibit viral DNA polymerase and cause chain termination?

Answer 24

Acyclovir & Valacyclovir

Question 25

Which topical antiparasite is directly absorbed, kills parasitic arthropods, and is used to tx head and crab lice?

Answer 25

Lindane

Question 26

Which antiparasite drug has potential for neurotoxicity and hematoxicity and should have caution in infants, children, and pregnant women?

Answer 26

Lindane

Question 27

Which topical parasite has scabicidal activity and has antipruritic effects?

Answer 27

Crotamiton

Question 28

Which topical antiparasite inhibits sodium ion influx via and has delayed repolarization in order to tx scabies?

Answer 28

Permethin

Question 29

Which antiparasitic drug binds to glutamate-gated chloride channels and increases permeability to chloride ions in order to tx onchocerciasis in immature form (river blindness) ?

Answer 29

Ivermectin

Question 30

(T/F) Ivermectin crosses the BBB but does have increased CNS toxicity when BBB is hyperpermeable (i.e meningitis)?

Answer 30

TRUE

Question 31

which oral drug increases calcium permeability and is effective against adult forms of schistosomes? (seizure in worm)

Answer 31

Praziquantel