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Integumentary > Cutaneous Manifestations w/ Systemic Disease > Flashcards

Cutaneous Manifestations w/ Systemic Disease Flashcards

1
Q

MC associated malignancy w/ cryoglobulinemia?

A

Multiple Myeloma

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2
Q

MC hepatitis associated w/ mixed cryoglobulinemia?

A

HCV

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3
Q

A pt presents with fragile skin w/ sclerodermoid changes. What should be part of routine investigative work up in pts w/ porphyria cutanea tarda?

A

HCV serology

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4
Q

A pt presents with purple, pruritic, polygonal papules and Wickham’s striae. most likely dx?

A

Lichen Planus

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5
Q

MC hepatitis associated w/ polyarteritis nodosa?

A

HBV

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6
Q

Excoriations, lichenification, and prurigo nodularis describe what?

A

Pruritis

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7
Q

Classical PAN, renal vasculitis, ANCA negative all point to what dx?

A

Hep. B

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8
Q

A pt presents w/ palmar erythema, gynecomastia, and multiple xanthomas in their palmar creases. What can this indicate?

A

Chronic liver disease

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9
Q

which hormone plays a pivotal role in the growth and formation of hair and sebum production?

A

thyroid hormone

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10
Q

What is the MC cystic abnormality of the neck? It presents as a mobile, nontender mass on the midline, anterior neck and is an embryonic duct remnant.

A

Thyroglossal duct cyst

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11
Q

Skin is usually ___, ___, and ____

A

warm, moist, and smooth

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12
Q

Hyperhydrosis, hyper pigmentation in the creases of palms and soles but no buccal pigmentation can point to?

A

hyperthyroidism

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13
Q

most important non-specific cutaneous manifestations of hyperthyroidism?

A

1) localized/generalized hypertrichosis
2) plummer nails
3) vitiligo

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14
Q

What disease is associated w/ thyroid dermopathy and symmetric, nonpitting yellow-brown waxy papules/plaques and is due to increased hyaluronic acid?

A

Graves disease

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15
Q

What nail condition is described as concave contour and distal onycholysis?

A

Plummer’s nail in hyperthyroidism

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16
Q

Clubbing of the fingers and toes in Graves’ disease associated w/ soft-tissue swelling of hands and feet and w/ periosteal new bone formation is termed:

A

thyroid acropachy

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17
Q

What describes the process in which binding of excess organic iodide in the thyroid gland results in inhibition of thyroid hormone synthesis occurring in pts w/ erythema nodosum being tx w/ potassium iodide?

A

wolff-chaikoff effect

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18
Q

Numerous firm white, yellow, or pink papules on face, trunk, axillae, and extremities describe..?

A

scleromyxedema in hyperthyroidism

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19
Q

Non-specific cutaneous manifestations of hypothyroidism include:

A

1) yellowish hue secondary to carotenemia
2) generalized myxedema (swollen waxy appearance
3) Madarosis (loss of lat. 3rd of eyebrow)

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20
Q

A pt presents with bruising, brittle nails, and purpura. What can this indicate?

A

Hypothyroidism

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21
Q

What syndrome is autosomal dominant and is characterized by medullary thyroid carcinoma, pheochromocytoma, marfanoid features, and GI ganglioneuromatosis?

A

MEN 2b/III

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22
Q

MC skin finding in MEN 2b/III?

A

mucosal neuromas

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23
Q

What is known as sipple syndrome and is associated with macular amyloidosis?

A

MEN 2A

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24
Q

Autosomal dominant and is associated w/ mucosal neuroma?

A

MEN 2b

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25
Q

Earliest cutaneous finding seen in tubular sclerosis?

A

hypopigmented (ash-leaf) macules

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26
Q

MC renal finding in tubular sclerosis?

A

angiomyolipomas

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27
Q

MC ocular findings in tubular sclerosis?

A

Phakoma (retinal hamartoma)

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28
Q

MC cutaneous finding in Fabry’s diease?

A

angiokeratomas

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29
Q

MC ocular finding in Fabry’s disease?

A

whorl corneal opacities

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30
Q

nail manifestation of cirrhosis or hypoalbuminemia resulting in whitening of the proximal 2/3, while the distal 1/3 is red?

A

terry’s nail

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31
Q

MC cutaneous manifestation of end-stage renal disease?

A

Pruritus

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32
Q

What is associated with high mortality and abnormally elevated levels of PTH? Pt would present with violaceous mottling of the skin that’s acutely painful due to ischemia

A

Calcific Uremic Arteriolopathy

Calciphylaxis

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33
Q

Uremic frost consist of?

A

white or yellowish coating or urea crystals on the beard area & other parts face, neck, or trunk
note: BUN would be increased

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34
Q

Nail manifestation of ESRD caused by edema of the nail bed and capillary network giving the proximal 1/2 of the nail on opaque white appearance?

A

Lindsay’s nails

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35
Q

Dapsone & lasiks are usually the MC cause of this?

A

Pseudoporphyria

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36
Q

disease associated w/ malar erythema, discoid plaques, photosensitivity, raynaud’s phenomenon, and periungal erythema?

A

SLE (systemic lupus erythematous)

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37
Q

which disease is associated w/ “mask like facies” and smoothening of lines of facial expressions?

A

systemic sclerosis

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38
Q

what disease presents with palpable purpura, gingival hyperplasia, and livedo reticularis?

A

wegener’s granulomatosis

39
Q

type 1 HHT is associated with a mutation in?

A

TGF-B

40
Q

type 2 HHT is associated w/ a mutation in?

A

ALK-1

41
Q

MC initial presenting sx in Osler-Weber-Rendu syndrome/HHT?

A

Epistaxis

42
Q

What disease is associated with HHV-8 and primary effusion lymphoma, solid lymphoma, and castleman’s disease?

A

Kaposi’s sarcoma

43
Q

What disease is associated with palpable purpura, mainly in children, and chronic kidney disease?

A

Henoch Sconlein purpura

44
Q

MC location for hamartomatous polyps in the GI tract seen in Peutz-Jeghers syndrome?

A

Small intestine

45
Q

Cutaneous findings in Peutz-Jeghers syndrome?

A

Lentigines on mucosa; periorificial skin, palms and digits

46
Q

Autosomal dominant disorder and variant of Lynch syndrome?

A

Muir-Torre syndrome

47
Q

MC malignancy associated w/ Muir-Torre?

A

Colon adenocarcinoma;

pts should be screened at 25 y/o, every 2-3 yrs

48
Q

MC location of colon adenocarcinoma?

A

right-sided colon

49
Q

symmetric, grouped vesicles on extensors and very pruritic and most commonly includes gluten sensitive enteropathy?

A

dermatitis herpetiformis

50
Q

MC cutaneous manifestation of inflammatory bowel disease is?

A

Erythema nodosum

51
Q

Tender red nodules on the anterior lower legs is known as?

A

erythema nodosum

52
Q

MC IBD associated w/ erythema nodosum?

A

Ulcerative colitis; more common in females

53
Q

Linear ulcerations, cobblestoned oral mucosa is indicative to?

A

oral crohn’s

54
Q

MC IBD associated with chronic apthous ulcers or pyostomatitis vegetans?

A

Ulcerative colitis

55
Q

MC IBD associated with pyoderma gangrenosum?

A

Ulcerative colitis

56
Q

What do you tx pyoderma gangrenosum with?

A

steroids

57
Q

what disease is a defect in neurofibromin and has crowe’s sign?

A

Neurofibromatosis 1 (AD)

58
Q

disease associated with mutation in ATM gene and present w/ Ataxia?

A

Ataxia-Telangectasia (AR)

59
Q

disease associated w/ premature aging, photosensitivity, and mutation in XP A-G?

A

Xeroderma Pigmentosum (AR)

60
Q

Associated w/ mutation in NEMO gene involves peg-shaped teeth?

A

Incontinentia Pigmenti (XLD)

61
Q

Associated w/ C-KIT, white forelock and impaired motor coordination?

A

Piebaldism (AD)

62
Q

Syndrome that presents congenital ichthyosis, di/tri tetraplegia, MR. Also associated w/ a scaly, spastic, seizing swede?

A

Sjorgen-Larson Syndrome (AR)

63
Q

Mutation in ATP7A, presents w/ doughy skin, kinky hair, severe psychomotor retardation and seizures?

A

Menke’s disease (XLR)

64
Q

difference in lesions for type I vs type II diabetes?

A

type I–> autoimmune lesions

type II–> cutaneous infxns

65
Q

MC endocrine abnormality associated w/ acanthosis nigricans?

A

diabetes mellitus

66
Q

MC associated malignancy w/ acanthosis nigricans?

A

gastric carcinoma

67
Q

Skin disorder seen in DM type II chracterized by painless, symmetric, woody “peau d’orange” induration of the upper back and neck?

A

scleredema diabeticorum

68
Q

Other than uncontrolled diabetes, what other settings may eruptive xanthomas occur?

A
  • hypertriglyceridemia (>2000 mg/dl)
  • Meds: retinoids, estrogens
  • Alcohol
69
Q

What are other conditions associated w/ diabetes?

A
  • vitiligo
  • lichen planus
  • hemochromatosis
70
Q

White, curd-like material adherent to erythematous, fissured oral commisure depicts?

A

angular cheilitis

71
Q

What is a common skin infxn in DM and is caused by pseudomonas aeruginosa?

A

malignant otitis externa

72
Q

What describes sharply demarcated erythematous patches and is caused by gram + corynebacterium minutissimum?

A

erythasma

73
Q

syndrome associated w/ defect in fibrillin 1 and upward lens dislocation?

A

marfan’s syndrome

74
Q

Disease associated w/ downward lens dislocation and elevated homocysteine?

A

Homocystinuria (AR)

75
Q

Disease associated w/ defect in COL3A1 and translucent skin/easy bruising?

A

Ehlers-Danlos IV (AD)

76
Q

AD syndrome associated w/ defect in PTPN11. Presents w/ Lentinges, Ekg changes, Ocular hypertelorism, Pulmonic stenosis, Arterial abnormalities, Retarded growth, Deafness

A

LEOPARD syndrome (AD)

77
Q

Paraneoplastic dermatoses associated w/ growth of fine lanugo hairs and is MC associated w/ lung carcinoma?

A

hypertrichosis lanuginosa

78
Q

MC associated malignancy w/ acquired ichthyosis?

A

Hodgkins Lymphoma

- dx made after mlaignancy

79
Q

MC associated malignancy w/ erythema gyratum repens:

A

lung carcinoma

80
Q

“wood grain” concentric erythematous bands w/ trailing edge of scale describes what condition?

A

erythema gyratum repens

81
Q

What syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous glucocorticoids? Pt presents w/ buffalo hump and striae!

A

Cushing syndrome

82
Q

MC associated malignancy associated w/ cushing syndrome?

A

Oat cell lung carcinoma

83
Q

Pt presents w/ flushing and erythema of head & neck and is dx with symptomatic carcinoid syndrome. MC associated malignancy?

A

ileal tumors

84
Q

MC associated malignancy w/ asymptomatic carcinoid syndrome?

A

neoplasm originating in the endocrine argentaffin cells of the appendix

85
Q

MC location of metastasis of carcinoid syndrome-causing tumors?

A

Liver

86
Q

Syndrome MC associated w/ AML and presents w/ erythematous tender papules, nodules, and plaques with marked lesional edema?

A

sweet’s syndrome

87
Q

(T/F) Malignancy associated sweet syndrome occurs in individuals w/ previously undiagnosed or relapsing hematologic malignancies (10-20%) and solid tumors

A

TRUE

88
Q

Associated malignancies associated w/ cryoglobulinemia?

A

multiple myeloma & waldrenstroms macroglobulinemia

89
Q

sudden development of numerous seborrheic keratoses and MC associated malignancy is gastric or colon carcinomas?

A

Lesser Trelat sign

90
Q

Which subtype of systemic amyloidosis is most commonly associated w/ malignancy (i.e: multiple myeloma) and presents w/ pinched purpura?

A

AL subtype

91
Q

Seen in Sezary syndrome, lyphomas, and leukemias:

A

Erythrodema

92
Q

condition associated w/ MGUS?

A

scleromyxedema

93
Q

Can be a marker for internal neoplasia and most commonly associated w/ ovarian cancer (women)? Pt presents w/ Shawl and Holster sign

A

dermatomyositis

94
Q

MC associated malignancy w/ dermatomyositis in men:

A

gastric carcinoma

Integumentary (4 decks)

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