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Clin Med1 1 > Derm Cancers 1 > Flashcards

Derm Cancers 1 Flashcards

0
Q

Mast cells, basophils

A

Type 1 immunology

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1
Q

skin colored, erythematous or yellowish

A

Squamous Cell Carcinoma (SCC)

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2
Q

Type 1 Immunology

A
  • IgE (ER)
  • Mast cells, basophils
  • e.g. Hives
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3
Q

cytotoxic

A

Type II immunology

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4
Q

Immune complex

A

Type III immunology

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5
Q

Type III imm

A
  • immune (antigen-ab) complex
  • platelet damage, vascular permiability
  • vasculitis
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6
Q

cell-mediated immunity

A

Type IV

poison ive

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7
Q

blistering diseases

A

defect in Basement Membrane Zone (BMZ)

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8
Q

what affects mucous membrane and causes pustules?

A

candida

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9
Q

SK Tx

A
  • reassure
  • cosmetic:cryotherapy, curettage with electo…., shave
  • excisional biopsy
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10
Q
  • greasy
  • stuck on
  • tan to black
  • 2mm-3cm
  • trunk but anywhere
A

Seborrheic Keratosis (SK)

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11
Q
  • tan to black papule
  • irregular but well-circumscribed
  • 2mm-3cm
A

Seborrheic Keratosis (SK)

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12
Q
  • suddenly many SK

- with many skin tags

A

Lesler-Trelat sign

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13
Q
  • sign of internal malignancy
  • many skin tags
  • suddenly many SK
A

Lesler-Trelat sign

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14
Q
  • rapid growth (4-6 wks)
  • biologically Benign but histologically SQUAMOUS CELL melanoma
  • resolves on its own within 6 months
  • round flesh colored nodule
A

keratoacanthoma

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15
Q

flesh colored, round nodule

rapid

A

keratoacanthoma

16
Q

keratoacanthoma

A
  • flesh colored, round nodule
  • rapid (4-6 wks)
  • resolves within 6 months
  • resembles SCC
17
Q
  • benign but often precursor to SCC
  • <1 mm - several cm
  • skin colored, white or light (can be pink)
  • scale or rough patch
  • FELT more easily
A

Actinic Keratosis (AK)

18
Q

Actinic Keratosis (AK) Tx

A

5-FU cream/imiquimod
cosmetic: cryotherapy, curettage, shave, biopsy
chem peels

19
Q

benign precursor to SCC

sun exposure

A

Actinic Keratosis (AK)

20
Q
  • firm/hard nodule/papule, often depressed center
  • “Pearly” “waxy”, rolled borders
  • teleangiectasias
  • few mm-1 cm
  • pink/red, pale yellow, translucent
A

Basal Cell Carcinoma (BCC)

21
Q

Basal Cell Tx

A
  • biopsy if ? ab Dx
  • refer to derm for any skin cancer
  • cosm: cryotherapy, curettage/electrodessication, excisional biopsy
  • MOHS
  • 5 FU, Imiquimod
22
Q
  • HEAD and FACE lesions most likely to metastasize

- low risk for met

A

SCC

23
Q

What condition can often lead to SCC

A

Actinic Keratosis (AK)

24
Q

SCC Tx

A
  • surgical resection (cure >90%)
  • MOHS if > 2cm and recurrent
  • Cosm: cryotherapy, curettage/electro
  • If metastasized: radiation, chemo
25
Q

Melanoma Tx

A
  • wide surgical excision with margins
  • elective lymph node dissection
  • Chemo: DTIC Dacarbazine
  • Immuno: interferon-alpha
  • Gene therapy
  • F/u q 3 months
26
Q

dermis

A
  • contains vessels, nerves, appendages
  • 1mm-4 mm
  • collagen, elastic fibers, ground substance
27
Q
  • 1st as flat/slightly raised discolored patch
  • IRREGULAR borders (vs. nodular is more regular)
  • tan, brown, red, blue white
  • RADIAL before VERTICAL
  • in previously benign mole
A

Superficial Spreading Melanoma

28
Q
  • long horizontal growth, then RAPID vertical
  • flat or mildly raised, mottles (spots)
  • older ppl, sun-exp
  • in situ turned invasive
  • shades of brown
  • subtype of MM
A

Lentigo Maligna

29
Q
  • rapid vertical growth (wks to months)
  • little/no radial growth
  • inflamed/friable nodule
  • black or any color
  • looks like superficial spreading melanoma
A

Nodular Melanoma

30
Q

most aggressive form of melanoma

A

nodular melanoma

31
Q

what looks like Superficial Spreading Melanoma?

A

Nodular Melanoma

32
Q

rapid vertical growth (wks to months)

A

Nodular melanoma

33
Q

ABCDs of melanoma

A
  • assymetry
  • border, irregular
  • color, uneven
  • diameter >6 mm
  • other: color spreads into surrounding skin, new nodule, inflammation beyond mole, tender, itch, bleeding, oozing
34
Q

sampling of melanoma

A

!!! ALWAYS require a FULL thickness biopsy!!!

!!! do NOT cauterize or shave !!!

35
Q
  • localized erythematous PATCH or plaque on TRUNK > 5 cm
  • itchy
  • Sezary cells later
  • Tx: refer to oncology/derm
A

Mycosis Fungoides (AKA Cutanious T Cell Lymphoma)

36
Q
  • may appear in previously benign mole
  • horizontal before vertical invasion
  • irregular borders
A

Superficial Spreading Melanoma

37
Q

Felt easier than seen

A

Actinic Keratosis

Scale or dry rough patch

Clin Med1 1 (8 decks)

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