Derm - Autoimmune Conditions

Question 1

what are the features of discoid lupus erythematous?

Answer 1

non itchy
disc shaped erythematous scaly plaques
heal leaving alopecia
on photosensitive exposed sites

Question 2

Ix for discoid lupus erythematous?

Answer 2

clinical
skin biopsy

test for SLE..
ANA
anti dsDNA
FBC, U+Es
urinalysis

Question 3

Tx for discoid lupus erythematous?

Answer 3

steroids

Question 4

what is the pathology in pemphigus vulgaris?

Answer 4

IgG antibodies against desmoglein

this is a protein in the epidermis

Question 5

features of pemphigus vulgaris?

Answer 5

flaccid bullae/vesicles
rupture to leave erosions
oral lesions

thorax
groin
axillae
scalp
face

Question 6

Ix for pemphigus vulgaris? results?

Answer 6

biopsy

IgG in surface of keratinocytes

Question 7

what sign is positive in pemphigus vulgaris? what does this show?

Answer 7

Nikolsky’s

loose skin slips free when rubbed

Question 8

Tx for pemphigus vulgaris?

Answer 8

steroids
analgesia
AZA

Question 9

what is the pathology behind bullous pemphigoid?

Answer 9

IgG antibodies react with antigens in the basement membrane

Question 10

features of bullous pemphigoid?

Answer 10

large tense bullae
erythematous base
no erosions
itch can be present

Question 11

Ix for bullous pemphigoid? results?

Answer 11

biopsy

DEJ shows IgG antibodies

Question 12

Tx for bullous pemphigoid?

Answer 12

steroids (topical or oral)
tetracyclines
AZA
ciclosporin

Question 13

features of lichen planus?

Answer 13

intense itch
flat topped shiny papules
on wrists/shins/ankles
wickham's striae on mucosa
koebner's phenomenon

Question 14

Tx for lichen planus?

Answer 14

topical steroids

antihistamines