Derm Flashcards
What is acne vulgaris?
Chronic inflammatory dermatosis caused by the obstruction of the pilosebaceous follicles in the face and upper trunk > results in comedones, inflammation and pustules
What are the causes of acne vulgaris?
Infantile acne (<3m)
Transient and usually due to increase in maternal androgens
Adolescent acne
Increased sebum production / impaired flow of sebum / Propionibacterium acnes
Associations
Puberty, POS, Cushing’s (excess cortisol)
What are the different types of acne lesions?
Comedones
Dilated sebaceous follicle
- Top is closed = whitehead
- Top is open = blackhead
Papules / pustules
Inflammatory lesions formed from follicles bursting and releasing irritants
Nodules / cysts
Excessive inflammatory response
- Ice-pick scars and hypertrophic scars
What are the S/S of acne?
- Greasy face
- Lesions
- Psychological impact > low self-esteem
- Can be painful
What are the investigations for acne?
Clinical diagnosis
If signs of androgen excess > free testosterone, FSH, LH, 24hr urinary cortisol
What is the management for acne?
Conservative:
- Cleaning face > avoid over-cleaning
- Avoid picking / squeezing due to risk of scarring
Medical:
1. Single topical therapy:
- Topical benzoyl peroxide or topical retinoids (e.g. adapalene)
2. Topical combination therapy:
- Topical abx (clindamycin 1%) + BPO/adapalene
3a. Oral abx (max 3m) + BPO/adapalene:
- 1st line = tetracyclines (lymecycline, doxycycline) > avoided in pregnancy
- 2nd line = macrolides (erythromycin) > can be used in pregnancy
3b. COCP + BPO/adapalene
- Alternative to oral abx
4. Dermatologist referral & oral isotretinoin
- Must be on 2 forms of contraception
- SE > dryness, pruritis, conjunctivitis, muscle aches, deranged LFTs
- Associated with low mood and suicidal ideation
Support
- NHS Choices leaflet on acne
- British Association of Dermatology
What is atopic dermatitis (eczema)?
Chronic, relapsing, inflammatory skin condition characterised by an itchy, red rash, commonly on flexures
What is the presentation of eczema in different age groups?
Typically presents before 2yrs but clears in ~50% by 5yrs and 75% by 10yrs
Infant = face and trunk
Older child = extensors of limbs
Young adult = localises to flexures
What are triggers of eczema?
- Irritants
- Contact allergens
- Extremes of temperature (worse in winter)
- Abrasive fabrics
- Sweating
- Dietary factors
- Inhaled allergens
What are the S/S of eczema?
Mild
- Areas of dry skin
- Infrequent itching
- +/- small areas of redness
Moderate
- Areas of dry skin
- Frequent itching
- Redness
- +/- excoriation and localised skin thickening
Severe
- Widespread areas of dry skin
- Incessant itching
- Redness
- +/- excoriation, extensive skin thickening, bleeding, oozing, cracking and alteration of pigmentation
What are the investigations for eczema?
- Infants with moderate/severe eczema + hx of immediate reaction to food = skin prick testing to common food allergens
- Eczema herpeticum = obs, swabs (bacterial superinfection)
What is the management of eczema?
Mild:
- Simple emollients, large quantities (50/50, Dermol, e45)
- Mild topical steroids (applied 30 mins after emollients)
Moderate:
- Emollients
- Moderate topical steroids (or topical calcineurin inhibitors e.g. Protopic)
- Wet wraps
Severe:
- Emollients
- Potent topical steroids (or topical calcineurin inhibitors)
- Wet wraps
- Systemic therapy (oral ciclosporin)
- Phototherapy
Infected:
- Oral flucloxacillin (erythromycin if pen allergic)
- Skin swab and culture
+ antihistamines if severe itching / urticaria
+ Information and support > itchywheezysneezy.co.uk , BAD , National Eczema Society
What is the management of eczema herpeticum?
Dermatological emergency
Rare but serious viral infection, normally causes by HSV
- Oral acyclovir
- If around the eyes > same day ophthalmologist referral
- Health education
How are emollients used in eczema?
- Use in large amounts and often
- Apply on the whole body
- Use as a soap substitute (also instead of shampoo or use unperfumed shampoos)
- Examples = e45, cetraben, diprobase, aveeno
Describe the steroid ladder?
- 1) Hydrocortisone
- 2) Eumovate
- 3) Betnovate
- 4) Dermovate
> SEs = infections, thin skin, stretch marks, systemic SEs
What is Naevus Flammeus?
Port-wine stain in distribution of trigeminal nerve
Vivid red/purple macule
- Sturge-Weber syndrome
- Parkes Weber syndrome
- Kippel-Trenaunay syndrome
- Proteus syndrome
> Mx = pulse dye laser
What is Naevus Simplex (salmon patches/stork bites/angel’s kiss)?
- A common, benign capillary vascular malformation
- Presents at birth as a pink or red patch
- Most often observed on nape of the neck, eyelid, or forehead
- Goes redder when the infant cries
What are the investigations for vascular malformations?
Clinical diagnosis
+ Imaging
1st = USS
2nd = MRI (Sturge-Weber)
What is the management for vascular malformations?
Conservative
What is a haemangioma?
Benign tumour made up of blood vessels that typically appear during the first weeks of life as blue or pink macules or patches, then enter a proliferative phase and become elevated above the surrounding skin surfaces
What’s the difference between infantile and congenital haemangioma?
Infantile haemangioma = develops a few days/weeks after birth.
Congenital haemangioma = always present at birth. Much rarer.
What are the RFs for haemangioma?
- LBW, prematurity
- White ethnicity
- Female
- Maternal multiple gestation
- Advanced maternal age
What are the S/S of haemangioma?
Superficial (50-60%)
- Bright red area of skin and feels warm
- Upper eyelids, midforehead, nape of neck
Deep (15%)
- Blue in colour, forms a lump
- May just look like a lump of normal skin
Mixed
- Bright red area on blue, forms a lump
Kasabach-Merritt
- Haemangioma with thrombocytopenia
What is the difference between a haemangioma and a vascular malformation?
Hemangiomas are vascular tumours that are rarely apparent at birth, grow rapidly during the first 6 months of life, involute with time and do not necessarily infiltrate but can sometimes be destructive.
Vascular malformations are irregular vascular networks defined by their particular blood vessel type, grow slowly throughout life but do not shrink, and usually require treatment.
What are the investigations for haemangioma?
Clinical diagnosis
- Doppler USS used to distinguish infantile haemangioma from vascular malformation
- USS > MRI/MRA gold standard to dx complex vascular tumours if lesions are:
o Deep
o Multiple haemangiomas
o Single large capillary haemangioma
o Near the eye - Medical photography
What is the management for haemangioma?
Conservative:
- Education and reassurance
If functional impairment / cosmetic disfiguration:
- Topical beta blocker and/or CS
- Surgical excision as the adjunct
If ulceration:
- Add astringents and barrier protection
- Adjunct > topical abx, becaplermin, analgesia
What is erythema toxicum?
- Common rash seen in full-term newborns
- Usually appears in first few days after birth and fades within a week
- Up to half of all newborns will have it
What are the S/S of erythema toxicum?
- Maculo-papular-pustular lesions > last for 1 day at a time
- Wax and wane over the first few days / weeks of life
- Begins on face and spreads to limbs
- Must exclude congenital infection
What is the management of erythema toxicum?
Self-limiting
What is Milia?
White pimples on nose and cheeks from retention of keratin and sebaceous material of the pilosebaceous follicle
What is strawberry naevi?
= Infantile haemangioma
Common type of birthmark that is usually red or purple
- Can occur anywhere (usually on face, often on the head and neck areas)
- Develop shortly after birth (presents ~3m)
- Complications = ulceration, bleeding, infection
Describe neonatal milia
- Affects ~50% of newborns
- Often nose, but also mouth, palate, scalp, face, upper trunk
- Heal spontaneously within a few weeks