Depressive Disorders Flashcards
What is the Pathophysiology of Major Depressive Disorder?
Dysreg of Neuro Transmitter systems
Alt of Neuropeptides
Hormone Disturb
Alt in Cereb BF
What are the criteria for a Major Depressive Episode?
> 2 weeks >5 symptoms 1 needs to be depressed mood or loss of interest/pleasure
What are the diagnostic symptoms of Major Depressive Disorder?
Depressed mood Anhedonia Sig Change in Appetite/Wt Sig Change in Sleep habits Psychmotor agitation/retard Fatigue Feel worthless or guilt Dimin conc or decision making thoughts of death or suicide
Which gender are more likely to experience a depressive episode?
Women 2x as likely
What is the Difference between MDD and Persistent Depressive disorder?
MDD: One or more episodes. no manic, hypomanic or mixed episodes
PDD: Chronic, Low level depressed mood >2 years
What needs to be done before beginning Tx for MDD?
Rule out medical causes, Dx, Substance use, Manic/psychotic symptoms, FHx, Suicidality, Past Tx outcomes, Patient Pref
What is the Tx for Major Depressive Disorder?
Psychopharm, PsychoThx
Alt Med, ECT, Mag Stim, Vagal nerve stim, Ketamine and NMDA receptor rec antagonist,
Exercise, Sleep, nutrition, social support
What are the types of Antidepressant Drugs?
MAOI
Tricyclic Antidepressants
SSRI
SNRI
What are the General principals for Anti-Dep Pharm
Black Box warning Onset of action Response vs Remission Anxiolytic Properties Compliance
Waht is included in the DDx of MDD?
Normal Sadness Grief Adjustment Disorder w/ DM Persistent DD MAnic episode w/ irr mood Dementia Mood disorder from GMD Subst induced Mood Disorder
What should be done before beginning Treatment?
Rule out medical causes Establish Diagnosis Assess substance abuse Mania/Psychosis? Preferences? FHx? Suicidality?
What is the Tx of MDD?
Psychopharm and PsychoTherapy
