Depression Flashcards
M:F depression
1:2
What is the lifetime prevalence of depression symptoms?
10-20%
What % of those w/ depression will recover within a year?
50-60%
What % of those w/ depression will it become chronic?
10-25%
What % of those with depression will die by suicide?
5-15%
Within 10 years, what % of those once diagnosed with depression will have a relapse?
75%
What are the 3 core symptoms of depression?
Low mood
Anhedonia
Anergia
Biological symptoms of depression (2)
Disturbed sleep
Changes in appetite
Cognitive symptoms of depression (6)
Reduced concentration or memory Poor self esteem Ideas of guilt + unworthiness Hopelessness Pessimism about the future Ideas/acts of self-harm/suicide
Neurotic/reactive depression
Patient is to some degree ‘understandably’ depressed, reacting to adverse psychosocial circumstances
Features of ‘Somatic Syndrome’ (8)
Markedly reduced appetite W loss - >5%W 1 month Early morning wakening Diurnal variation in mood Psychomotor retardation/agitation Loss libido Marked anhedonia Lack emotional reactivity
Depressive stupor
Causes someone to remain speechless + motionless for an extended period
Depression w/ psychosis
Definition of a mild depressive episode
At least 2/3 core symptoms
+ additional Sx –> 4
w/ or w/o somatic syndrome
Definition of moderate depressive episode
At least 2/3 core Sx
+ additional Sx –> 6
W/ or w/o somatic syndrome
Definition of severe depressive episode
All 3 core Sx
+ additional Sx –> 8
Definition of severe depressive episode w/ psychotic Sx
All 3 core Sx
+ additional Sx –> at least 8
+ delusions, hallucinations or depressive stupor
Organic DDx depression (5)
Neuro - MS/PD/HD/CVA
Endocrine - thyroid/parathyroid, Cushings/Addisons
Infections
Iatrogenic - opiates. L-dopa, steroids
Others - malignancies, SLE, RA, renal failure, porphyria, chronic pain, IHD
phsyical Ix - depressive pt
FBC - anaemia/infection/MCV (alcohol)
U+E
LFT - GGT
TFT +Ca
What is the most common co-morbidity - depression
Substance abuse
How is depression managed?
Via NICE’s Stepped care approach
Step 1 NICE stepped care for depression
For all known/suspected PS of depression: Assess Active monitoring Psychoeducation Computer CBT Sleep hygiene Guided self-help
Step 2 NICE stepped care for depression
Mild/mod depression - 1’ care:
Low intensity psychological interventions
Meds - 1st line = norm SSRIs
Step 3 NICE stepped care for depression
Mod/severe depression. Failure to respond to Tx. 1’ care:
Meds
High-intensity psychological intervention
Consider 2’ care referral
Step 4 NICE stepped care for depression
Sever complex depression. Life threatening/severe self-neglect: Meds - venlafaxine/mitrazapine/tca/MAOIs High intensity psycho interventions MDT Inpt care
If 1 episode of depression, how long should meds be continued for after pt is feeling better?
6 months
If recurrent depression, how long should meds be continued for after pt is feeling better?
2 years
Indications - antidepressants (10)
Depressive illness Anxiety Neuropathic pain Insomnia Bulimia Impulsivity Migraines Chronic fatigue Syndrome IBS Nacrolepsy
SSRIs - e.g.s (6)
Fluoxetine Paroxetine Sertraline Escitalopram Citalopram Fluvoxamine
Time taken between initiation and response - SSRIs
1-6 w
SE of SSRIs (9)
Nausea Exacerbation of anxiety Insomnia Apathy/fatigue Diarrhoea Dizziness Sweating Restlessness Sexual dysfunction
E..g.s of SNRI (2)
Venlafaxine
Duloxetine
SE SNRIS
Similar to SSRIs
More sedation
Greater discontinuation Sx