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Pharmacology > Depression > Flashcards

Depression Flashcards

1
Q

What class of drugs does sertraline belong to?

A

SSRI

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2
Q

What class of drugs does citalopram belong to?

A

SSRI

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3
Q

What class of drugs does fluoxetine belong to?

A

SSRI

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4
Q

What class of drug does venlafaxine belong to?

A

SNRI - serotonin norepinephrine reuptake inhibitor

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5
Q

What class of drug does mirtazapine belong to?

A

presynaptic alpha 2 adrenergic receptor antagonist

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6
Q

What is the mechanism of action of sertraline?

A

inhibits serotonin reuptake in accumulation of serotonin

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7
Q

What is the mechanism of action of citalopram?

A

inhibits serotonin reuptake in accumulation of serotonin

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8
Q

What is the mechanism of action of fluoxetine?

A

inhibits serotonin reuptake in accumulation of serotonin

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9
Q

What is the mechanism of action of venlafaxine?

A

a more potent inhibitor of serotonin reuptake than norepinephrine reuptake. - noradrenaline is implicated in regulation of emotions and cognition

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10
Q

What is the mechanism of action of mirtazapine?

A

antagonises central presynaptic alpha 2 adrenergic receptors which causes an increased release of serotonin and norepinephrine
it also antagonises central 5HT2 receptors, leaving 5ht1 receptors readily available which trigger anti depressant effects

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11
Q

What is the drug target of sertraline?

A

serotonin transporter

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12
Q

What is the main side effect of sertraline?

A

GI effects, sexual dysfunction, insomnia, mild dopamine inhibition

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13
Q

Why must sertraline be gradually decreased on discontinuation?

A

can result in discontinuation syndrome

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14
Q

What is the drug target of citalopram?

A

serotonin transporter

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15
Q

What are the side effects of citalopram?

A

GI effects, sexual dysfunction, anxiety, insomnia

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16
Q

What other receptors does citalopram antagonise?

A

muscarinic and histamine receptors

17
Q

What enzyme is citalopram metabolised by?

A

CYP2C19

18
Q

Why must citalopram be gradually decreased on discontinuation?

A

can develop discontinuation syndrome

19
Q

What is the drug target of fluoxetine?

A

serotonin transporter

20
Q

What are the side effects of fluoxetine?

A

GI effects, sexual dysfunction, anxiety, insomnia

21
Q

What other receptors does fluoxetine antagonise?

A

5hta and 5htc

22
Q

What enzymes does fluoxetine inhibit?

A

cyp2d6, cyp2c19

23
Q

What is the drug target of venlafaxine?

A

serotonin transporter

noradrenaline transporter

24
Q

What are the side effects of venlafaxine?

A

GI effects, sexual dysfunction, anxiety, insomnia, hypertension at very high doses

25
Q

Why must all SSRI’s be discontinued slowly?

A

may develop discontinuation syndrome

26
Q

What is the drug target of mirtazapine?

A

alpha 2 receptor

5-ht2 receptor

27
Q

What are the side effects of mirtazapine?

A

weight gain, sedation

Pharmacology (8 decks)

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