Asthma Flashcards
What is the primary mechanism of action of salbutamol?
agonist at the beta 2 receptor on airway smooth muscle cells. activation reduces calcium entry and this prevents smooth muscle contraction
What is the drug target of salbutamol?
beta 2 adrenergic receptor
What are the main side effects of salbutamol?
palpitations, tachycardia, hypokalaemia
What type of beta agonist is salbutamol?
short acting beta agonist
What is the half life of salbutamol?
2.5-5 hours
Why should you be careful administering salbutamol with corticosteroids?
hypokalaemia caused by effect on sodium potassium ATPase, which is exacerbated by coadministration with corticosteroids
What is the primary mechanism of action of fluticasone?
multiple actions on many different cell types, fluticasone directly decreases inflammatory cells such as eosinophils, monocytes etc, and also reduces the cytokines they produce
What is the drug target of fluticasone?
glucocorticoid receptor
What are the side effects of fluticasone?
sore throat, hoarse voice, oral infection, growth retardation in children, hyperglycaemia, decreased bone mineral density, immunosuppression
How is fluticasone delivered systemically?
inhaled, so passes through the pulmonary vasculature. the oral bioavailability is very limited
What is the primary mechanism of action mometasone?
mometasone also decreases inflammatory cells and reduces the number of cytokines they produce
What is the drug target of mometasone?
glucocorticoid receptor
What are the side effects of mometasone?
sore throat, hoarse voice, oral infection, growth retardation in children, hyperglycaemia, decreased bone mineral density, immunosuppression
How is mometasone delivered systemically?
inhaled, so passes through the pulmonary vasculature. the oral bioavailability is very limited
What is the primary mechanism of action of budesonide?
budesonide directly decreases inflammatory cells such as eosinophils, monocytes etc as well reducing the number of cytokines
