Depressed Mood Flashcards

1
Q

What does Anhedonia mean?

A

loss of pleasure and enjoyment

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2
Q

What does Anergia mean?

A

lack of energy

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3
Q

What does psychomotor retardation mean?

A

subjective slowing of thoughts

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4
Q

What is stupor?

A

absence of relational functions e.g. action and speech

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5
Q

What is the criteria to be diagnosed with depression?

A

depressive episode must have a 2 week history

there must be no hypomanic/manic symptoms sufficient to meet the criteria of hypomania/mania at any point in life.

At least 2 of core symptoms:
depressed mood, loss of interest or decreased energy

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6
Q

What are the additional symptoms of depression?

A
lack of confidence 
unreasonable feelings of guilt 
recurrent feelings of suicide 
diminished ability to concentrate 
appetite disturbance
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7
Q

What is the criteria for moderate depression?

A

2 core symptoms

4 additional symptoms

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8
Q

What is the criteria for severe depression?

A

3 core symptoms

5 additional symptoms

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9
Q

What are the sub-types of depression?

A

Somatic Syndrome
Atypical Depression
Psychotic Depression

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10
Q

What are the symptoms of somatic syndrome?

A
4 of the following: 
decreased pleasure in activities 
reduced emotional reactions 
sleep disturbances 
mood worse in the morning 
decreased weight and libido
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11
Q

How is somatic syndrome assessed?

A

MADRAS scoring

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12
Q

What is atypical depression?

A

mood reactivity
or
2 of the following:
weight gain, hypersomnia, leaden paralysis

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13
Q

What is mood reactivity?

A

change in mood in response to actual/potential events

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14
Q

What is leaden paralysis?

A

heavy feeling in legs and arms

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15
Q

What is psychotic depression?

A

occasional paranoid, typically mood-congruent or hypercondriacal
e.g. I’m being poisoned for my sins.

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16
Q

What is cotard’s syndrome?

A

nihilistic delusions - believing they have already died

17
Q

What is depression (neurobiology)?

A

altered sensitivity/accuracy of brain systems evaluating rewards and cues predicting reward within an environment

18
Q

Where are there increased numbers of 5HT receptors?

A

hippocampus

medial temporal cortex

19
Q

What are the 4 areas of the brain implicated in mood disorders?

A

orbital frontal cortex
Dorsolateral pre-frontal cortex
Hippocampus/Amygdala
Anterior cingulate cortex

20
Q

What gets secreted in abundance during a depressive episode?

A

Cortisol Releasing Factor from Hypothalamus

21
Q

What is caused by increased secretion of CRF during a depressive episode?

A

increased cortisol

22
Q

What happens when there is increased cortisol in circulation?

A

desensitisation of cortisol receptors leads to increased activity of macrophages and disturbances in noradrenaline/serotonin transmission