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Psychiatry > Anti-Depressant Drugs > Flashcards

Anti-Depressant Drugs Flashcards

1
Q

What are the 3 main categories of antidepressants?

A

Monoamine Oxidase Inhibitors
Monoamine Re-uptake Inhibitors
Atypical Drugs

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2
Q

What are 3 of the monoamine neurotransmitters?

A

Noradrenaline
Serotonin
Dopamine

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3
Q

Name 2 examples of MOIs?

A

Phenelzine

Moclobemide

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4
Q

What are common side effects of MOAis?

A

cheese effect
postural hypotension
peripheral oedema

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5
Q

What is the cheese effect?

A

hypertensive crisis cause by inhibition of MAO-A in the gut

therefore, not breaking down Tyramine

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6
Q

What does MOAis bind to?

A

MOA-receptors A + B

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7
Q

What are the different sub-types of monoamine reuptake inhibitors?

A

Tricyclic
SSRIs
Noradrenaline re-uptake inhibitors

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8
Q

What are examples of tricyclic antidepressants?

A

Imipramine

Amitriptlyine

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9
Q

How do tricylicics woek?

A

blocks re-uptake of monoamines (mainly noradrenaline and serotonin)

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10
Q

What are the side effects of tricyclics?

A

blurred vision
dry mouth consipation
urinary retention
sedation

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11
Q

what is the risk in an overdose of trycyclic?

A

cardio-toxic in OD

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12
Q

what are examples of SSRIs?

A

Sertraline
Fluoextine
Citalopram

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13
Q

How do SSRIs work?

A

selectively inhibit 5HT from the pre-synaptic cleft

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14
Q

What are the side effects of SSRIs?

A

GI upset
sexual dysfunction
discontinuation effects

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15
Q

What is important to remember with SSRIs when prescribing?

A

transient increased risk of self harm and suicide in <25 year olds.

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16
Q

What is important to note for Fluoextine?

A

Licensed in children

17
Q

What is important to note for Sertraline?

A

good cardiac safety

18
Q

How do Venalaxine and Duloxetine work?

A

blocks the uptake of monoamines NA and 5HT in pre-synaptic terminals

19
Q

Name an atypical antidepressant?

A

Mirtazapine

20
Q

What are the side effects of Mirtazapine?

A

increased weight

sedation

21
Q

What happens when Mirtazapine is given in conjunction with SSRIs?

A

Mirtazapine blocks all serotenergic side effects

Psychiatry (6 decks)

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