Dep/Anx

Question 1

Common side effects of all SSRIs

Answer 1

sexual dysfunction, drowsiness, weight gain, insomnia, anxiety, dizziness, headache, and dry mouth

Question 2

Mirtazapine

Answer 2

Alpha 2 adrenergic antagonist (TCA) = increased serotonin and NE.
High H1 affinity
Good for insomnia or eating disorder
Biggest side effect: Drowsiness, sedation, weight gain

Question 3

Sertraline

Answer 3

PPD, Pregnancy

Question 4

MAOIs

Answer 4

3rd line for persistent depression
Selegiline
Irreversibly block monoamine oxidase, increasing serotonin, norepinephrine, and dopamine
Patient must avoid tyrosine in food. Fermented foods and cheeses

Question 5

SNRIs prolong QTc?

Answer 5

NO!

Question 6

TCAs

Answer 6

3rd line for depression
Amitriptyline
Side effects: QTc prolongation and heart arrythmias

Question 7

Bupropion

Answer 7

Contraindicated for seizures or eating disorder or on MAOI.
Good for smoking cessation or if they need energy. No sex dysfunction.
Blocks DOPAMINE and NE reuptake
Side effects: Lowers seizure threshold, worsens SI initially

Question 8

Paroxetine

Answer 8

SSRI
Most sedating

Question 9

Fluoxetine

Answer 9

SSRI
Only agent approved by the Food and Drug Administration for bulimia
Longest half life of SSRIs

Question 10

Serotonin Syndrome

Answer 10

Fast, hot, mydriasis
MCC by SSRIs
Treat with Benzos first
Cyproheptadine second

Question 11

Venlafaxine

Answer 11

SNRI
Can cause HTN

Question 12

Duloxetine

Answer 12

SNRI
Great for pts with significant fatigue or neuropathy pain