dendritic cells Flashcards
1
Q
dendritic cells bear the ____ surface antigen
A
CDIIc
2
Q
where are DC cells dervived from
A
bone marrow
3
Q
conventional DCs (cDCs)
A
in mice further divided into CD8a+ and CD8a-
4
Q
CD8a+
A
- good at eating dead cells and cross presentation
- major producer of IL-12
- lymphoid resident
5
Q
CD8a-
A
- express CDIIb
- majority of cDCs inmice
- migrate from tissue to lymph node
- tolerogenic properties
6
Q
langerhans cells
A
- express CDIa, langerin
- migrate from skin to lymph node
- arise froma skin resident progenitor population
7
Q
CD103 intestinal DCs
A
- found in lamina propria of intestine and mesenteric lymph nodes
- mostly CDIIb and CD8a-
- express TLR5 and TLR9
- induce gut homing T cells - Treg cells
- important for oral tolerance
8
Q
plasmacytoid DCs (pDCs)
A
- have higher levels of TLR 7,8,9
- large producers of IFNa (respond to viruses)
9
Q
IL-12
A
- heterodimer: p35 and p40
- skews CD4+ T cells towards Th1
- enhanced CD8+ T cell effector responses
10
Q
IL-6
A
- drives fever, inflammation, acute phase response
- skew CD4+ T cells towards Th17
- helps with B cell differentiation and antibody production
11
Q
IL-10
A
- anti-inflammatory cytokine
- inhibits CD8+ T cell effector responses
- may help to skew CD4+ T cells towards Treg phenotype
inhibits T cells by inhibiting DCs
