Cytokines/Chemokines

Question 1

IL-1B, a

Answer 1

proinflammatory, fever

Question 2

IL-2

Answer 2

T cell growth factor

Question 3

IL-4

Answer 3

B cell growth factor, promotes Th2 cells, IgE isotype, induces alternatively activated macrophages

kills helminths

Question 4

IL-5

Answer 4

eosinophil growth factor

Question 5

IL-6

Answer 5

proinflammatory

Question 6

IL-10

Answer 6

inhibits T cell and macrophage function

anti-inflammatory

Question 7

IL-12

Answer 7

stimulates NK cells and T cells to make IFNg

Question 8

IL-13

Answer 8

induces alternatively activated macrophages

Question 9

IL-15

Answer 9

T cell growth factor

Question 10

IL-17

Answer 10

proinflammatory, increases neutrophil recruitment

Question 11

IFN-y

Answer 11

activates macrophages, upregulates Class II, promotes IgGa isotype Abs

Question 12

TNF

Answer 12

proinflammatory

Question 13

TGF-B

Answer 13

increases IgA, inhibits immune responses, promotes wound healing, promotes Treg cells

Question 14

IFN a,B

Answer 14

anti-viral cytokine

Question 15

IL-21

Answer 15

important for Tfh help for B cells

Question 16

IL-31

Answer 16

proinflammatory

Question 17

Which trio of proinflammatory cytokines are made by macrophages (and other innate cells)?

Answer 17

TNF, IL-6, IL-1B,a

Question 18

Which cytokine is produced by dendritic cells (typically in response to an intracellular infection) and provides a signal that encourages naive T cells to become Th1 cells?

Answer 18

IL-12

Question 19

Which cytokine is produced by Th2 cells and associated with the response against worms?

Answer 19

IL-4

Question 20

Which cytokine is produced by Th1 cells and helps activate macrophages, enhancing their phagocytic abilities?

Answer 20

IFN-y

Question 21

What category of signaling molecules recruits cells to a site of infection (chemokine or cytokine)? Which of the group of cytokines listed above is actually a chemokine?

Answer 21

chemokines, IL-8

Question 22

Which cytokine is “tolerogenic” (i.e. quiets the response rather than activate it)?

Answer 22

TGF-B

Question 23

Which cytokines trigger anti-viral responses in neighboring cells?

Answer 23

INF a,B

Question 24

You come across this paper in your search for new ways to diagnose and treat acute pancreatitis (inflammation of the pancreas) in your canine patients. Given what you have learned so far, which of the following cytokines might be present at higher concentrations in the serum? (i.e. What might an immunologist predict?)

a.) TNF-a
b.) IL-6
c.) IL-10
d.) TGF-B
e.) IL-1-B

Answer 24

TNF-a, IL-6, IL-1-B

Question 25

Which type of immune response would a goat with a nematode infection initiate?

a.) type 1 response
b.) type 2 response
c.) type 3 response

Answer 25

type 2 reponse

Question 26

Which of the following cytokines are classically associated with nematode infections?

a.) IL-10
b.) IL-4
c.) Il-12
d.) TGF-B

Answer 26

IL-4

Question 27

Two drugs that have been useful in the treatment of canine pruritis (itchiness) have the brand names Apoquel and Cytopoint. What cytokine signaling pathway do these two drugs target?

a.) IL-17
b.) IL-2
c.) IL-31
d.) Il-4
e.) IL-33

Answer 27

IL-31

Question 28

Which cytokine is really a chemokine?

a.) IL-2
b.) IL-8
c.) IL-6
d.) IL-4

Answer 28

IL-8

Question 29

“IFN is most frequently used for the treatment of virus infections in dogs and cats.” True or false: The authors are referring to Type II, not Type I interferons in this sentence (and context).

true or false

Answer 29

false