Demyelinating Disease Flashcards
1
Q
How does diphtheria affect myelin?
A
inhibits Schwann cell myelin synthesis
2
Q
MS is associated with HLA ___.
A
DR 2 and DR 4
3
Q
What is Charcot’s triad? Where is it seen?
A
nystagmus, scanning speech, intention tremor
MS
4
Q
B/l intranuclear ophthalmoplegia is pathognomonic for ______.
A
MS
5
Q
MS plaques on gross pathology are ____ if older and _____ if acute.
A
grey
pink
6
Q
Lymphocytes that are seen in MS are predominantly _____.
A
T cells
7
Q
In MS, steroids decrease ______, B-interferon decreases _____, and Copaxone decreases _____.
A
steroids - attack duration
B-interferon - attack rate
Copaxone - frequency of relapses
8
Q
What is Margburg variant (acute) MS?
A
rapidly fatal variant with diffuse large plaques
