Dementia - Lewy Body Dementia

Question 1

Pathophysiology of Dementia with Lewy Bodies.

Answer 1

LEWY BODIES : Alpha-Synuclein Cytoplasmic Inclusions in Substantia Nigra, Paralimbic and Neocortical Areas.

Question 2

Clinical Features of Dementia with Lewy Bodies (3).

Answer 2

1. Progressive Cognitive Impairment.
2. Parkinsonism.
3. Visual Hallucinations.

Question 3

Unique Features of the Progressive Cognitive Impairment in Dementia with Lewy Bodies (3).

Answer 3

1. Early Impairment in Attention and Executive Function rather than just Memory Loss (unlike Alzheimer’s).
2. Fluctuating Cognition.
3. Develops Before Parkinsonism.

Question 4

Diagnosis of Dementia with Lewy Bodies.

Answer 4

1. Clinical Diagnosis.

2. SPECT.

Question 5

Management of Dementia with Lewy Bodies.

Answer 5

1. Same as Alzheimer’s disease Management.

2. AVOID NEUROLEPTICS : Can trigger Irreversible Parkinsonism.