Dementia - Kruse

Question 1

AChE inhibitors approved for use in dementia

Why?

2 main dementias that these are used for?

Answer 1

• Donepezil
• Galantamine
• Rivastigmine
• Tacrine (HEPATOTOXICITY)

Dementia has a deficiency of cholinergic neurons

Alzheimer’s, Parkinsons

Question 2

Treatment for AChE inhibitor overdose?

Answer 2

Atropine
Pralidoxime (re-activator)

Question 3

Memantine - MoA (explain)

Answer 3

Alzheimer’s - glutamate may overstimulate various receptors, leading to neuronal cell death. During activation of the NMDA receptor, Mg leaves its intra-pore binding site and allows excess Ca++ influx.

MoA = antagonist at NDMA receptor by binding to Mg binding site (WHEN OVERLY ACTIVE) and preventing Ca++ influx

Question 4

Memantine - side effect (most common)

Answer 4

Dizziness