ADHD - Segars Flashcards
Function of STIMULANTS for ADHD
Enhance NE/DA/5-HT transmission via interfering with pre-synaptic reuptake by VMAT –> increased NT release
Stimulant drugs for ADHD
Amphetamine Dextroamphetamine Lisdexamphetamine Methamphetamine Methylphenidate Dexmethylphenidate
**ADHD Stimulant drugs - FDA regulations?
- 1 month supply
- No refills
- No samples
Side effects of amphetamine stimulants for ADHD
- Decreased appetite
- Insomnia
- HA, abdominal pain
- Irritability, aggression
- Elevated BP/HR – stroke, MI
Non-stimulant meds for ADHD
- Atomoxetine
- Guanfacine
- Clonidine
Function of NON-stimulants for ADHD
Enhance NT transmission via inhibiting re-uptake (Atomoxetine) of NE or activating CNS alpha-2 receptors (Guanfacine, Clonidine)
**Onset of activity for stimulants vs. non-stimulants
**Who is given the non-stimulant drugs for ADHD?
**Regulations on non-stimulant drugs for ADHD?
Stimulants = 24 hours Non = 2-4 weeks
Intolerance to stimulants or parent resistance to stimulants
NONE (not controlled)
Can non-stimulants be broken up and put in/on food?
NO
Different side effects of non-stimulants compared to stimulants?
- HYPOtension
- Dizziness
- Sedation/somnolence
Adderall
- Form?
- Drug(s)?
- Age?
- Percentage of each? (XR)
Pill
d,l-amphetamine, dextroamphetamine
3+
XR = 50/50
Dexedrine
- Form?
- Drug(s)?
- Age?
Spansules (capsule that releases drug over time)
Dextroamphetamine
3+
Vyvanse
- Form?
- Drug(s)?
- Age?
Pill
Lisdexamfetamine (pro-drug of dextroamphetamine)
6+
Concerta
- Form?
- Drug(s)?
- IR or DR?
- Percentage of each? (XR)
- Age?
Pill
d,l-methylphenidate
BOTH (2 phases)
22% immediate (outer coat), 78% delayed
6+
Ritalin
- Form?
- Drug?
- IR or DR?
- Percentage of each? (XR)
- Age?
Pill
d,l-methylphenidate
BOTH
50/50
6+
Metadate
- Form?
- Drug(s)?
- IR or XR?
- Percentage of each? (XR)
- Age?
Pill
d,l-methylphenidate
BOTH
30/70
6+
