Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psych > Anti-Psychotics -- Segars > Flashcards

Anti-Psychotics -- Segars Flashcards

You may prefer our related Brainscape-certified flashcards:
Psychology 101 flashcards GRE® Psychology flashcards
1
Q

Recurrent suicidal behavior – treatment

A

Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Schizophrenia - positive vs. negative symptoms

A

Positive = hallucinations, delusions, disorganized speech, agitation, behavioral dyscontrol

Negative = Apathy, avolition, alogia, cognitive deficits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Schizophrenia - cause of positive vs. negative symptoms

Name of this theory?

A 
Positive = increased post-synaptic D2 receptor activity in mesolimbic system
Negative = decreased D1 activity in pre-frontal cortex

Dopamine hypothesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Typical antipsychotic agents (3)

A

Haloperidol
ChlorpromAZINE
FluphenAZINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Atypical antipsychotic agents (8)

A

AriPIPRAZOLE
BrexPIPRAZOLE

ClozAPINE
OlanzAPINE
QuetiAPINE

PaliperIDONE
RisperIDONE
ZiprasIDONE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

***Major SE difference between the typicals and atypicals

A

TYPICALS have movement-disorder side effects (extrapyramidal symptoms)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MoA of antipsychotics (in general)

A

Block D2 post-synaptic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

**Partial agonists at D2/3 and 5HT-1A receptors

A

AriPIPRAZOLE

BrexPIPRAZOLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

**Blocker of NE reuptake transporter (NERT)

A

NorquetiAPINE (metabolite of QuetiAPINE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which agents are more likely to block D1 and D4 receptors also?

Which agents are more likely to block 5-HT receptors also?

A

ATYPICALS

ATYPICALS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

**Typical agent(s) – sedation, hypotension, seizures

Why?

A

Chlorpromazine

Low potency blocker of D2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

**Typical agent(s) – dystonia, akathisia, dyskinesia, parkinson-like symptoms

Why?

A

Fluphenazine
**HALOPERIDOL

High potency blockers of D2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

***Extrapyramidal symptoms (EPS) – treatments?

A

***Anticholinergics
- Diphenhydramine (Benadryl)
- Benztropine
- Trihexyphenidyl
Amantadine
Propranolol/Clonazepam (for akathisia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

**3 other receptors that can be blocked by antipsychotics and cause symptoms (w/ symptoms)

A

Muscarinic (dry mouth, constipation, blurred vision, etc.)

Alpha-adrenergic (orthostatic hypotension, impotence)

Histamine (SEDATION)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

**Non-behavioral side effect related to dopamine inhibition

A

Hyperprolactinemia – amenorrhea, erectile dysfunction, infertility, decreased libido, galactorrhea)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

***Agranulocytosis - drug cause?

Must do what?

A

Clozapine

Monitor WBCs

17
Q

Autonomic instability, stupor, hyperpyrexia, muscle rigidity, altered mental status

Cause?

A

Neuroleptic malignant syndrome (NMS)

Injectable, high-potency typical agents

18
Q

ALL patients taking antipsychotics should FIRST have what things measured/recorded?

***Why?

A

Glucose, lipids, weight, BP, waist size, FHx, etc.

Some (atypicals especially) may cause: weight gain, hyperlipidemia/hyperglycemia, QT prolongation

19
Q

**Highest risk of mortality from taking anti-psychotics

**Drugs? (4)

A

STROKE – in elderly w/ dementia

Aripiprazole, Olanzapine, Paliperidone, Risperidone

20
Q

Sedation (anti-histamine effect) – drugs? (3)

A

Chlorpromazine

Olanzapine
Quetiapine

21
Q

Anti-muscarinic effects – drugs? (3)

A

Chlorpromazine

**Clozapine
Olanzapine

22
Q

Orthostatic hypotension (anti-alpha effect) – drugs? (2)

A

Chlorpromazine

Clozapine

23
Q

QT prolongation/ECG changes – drugs? (4)

A

Chlorpromazine
Fluphenazine

Paliperidone
**ZIPRASIDONE

24
Q

EPS – drugs? (3)

A

***Haloperidol
Fluphenazine
Chlorpromazine

25
Q

Weight gain – drugs? (2)

A
  • **Clozapine

* **Olanzapine

26
Q

Hyperglycemia, Hyperlipidemia - drugs? (2)

A
  • **Clozapine

* **Olanzapine

27
Q

Seizures - drugs (3)

A

Chlorpromazine

Clozapine
Olanzapine

28
Q

Hyperprolactinemia - drugs? (2)

A

Haloperidol (other 2 are less)

Risperidone

29
Q

2 things to think about when choosing a drug

A

Previous dosing history (efficacy vs. SEs)

Tolerance to SEs

30
Q

**Patient w/ non-compliance can be treated w/ what?

**Drugs? (6)

A

Long-acting injectable agents

Typicals = Haloperidol, Fluphenazine

Atypicals = Risperidone, Olanzapine, Aripiprazole, Paliperidone

31
Q

Anti-psychotics in pregnancy?

A

ALL but 2 are Category C – can use if truly needed

Psych (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions