DEMENTIA Flashcards

1
Q

a syndrome resulting from acquired brain disease
characterized by a progressive decline in memory and
other cognitive domains

A

Dementia

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2
Q

What is Dementia?

A

due to disease of the brain, usually of a chronic or progressive nature, in which there is disturbance of multiple higher cortical functions (memory, thinking, orientation, comprehension,
calculation, learning capacity, language, and judgment)

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3
Q

T or F:

Dementia produces an appreciable decline in intellectual functioning, and usually some interference with personal activities of daily living

A

True

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4
Q

How can you differentiate dementia from other cog d/o?

A

You could differentiate dementia from other cognitive disorders because of its chronic and progressive nature

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5
Q

DIAGNOSTIC CRITERIA FOR DEMENTIA

A

● Insidious onset
● Not caused by delirium, schizophrenia, or major depression
● Acquired
● Persistent
● Affects several areas of mental function
● Severe enough to interfere with work, social activities, and relationships with others

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6
Q

T or F:

7th leading cause of death and one of the major
causes of disability and dependency among older people

A

True

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7
Q

Dementia prevalence in the PH

A

Dementia prevalence- 10.6%
○ AD: 85.5%
○ VaD: 11.7%

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8
Q

These are usually associated with vascular dementia but not with alzheimer’s disease

A

○ Hypertension
○ Diabetes
○ Dyslipidemia
○ Smoking

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9
Q

What is DALY?

A

time based measure combines years of life/loss due to
premature mortality, and years of life/loss due to time lived in states of full care health or years of healthy life/loss due to disability

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10
Q

represents the loss of the equivalent of 1 year of full health

A

1 DALY

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10
Q

risk factors for dementia

A

● Age (more common in those 65 or older)
● High blood pressure (hypertension)
● High blood sugar (diabetes)
● Being overweight or obese
● Smoking
● Drinking too much alcohol
● Being physically inactive
● Being socially isolated
● Depression

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10
Q

T or F

High blood pressure, diabetes, being overweight, smoking these are the ones that are not risk factors for vascular dementia but not for Alzheimer’s dementia.

A

False

High blood pressure, diabetes, being overweight, smoking these are the ones that ARE risk factors for vascular dementia but not for Alzheimer’s dementia.

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11
Q

Signs and Symptoms of Dementia

A
  • memory failure
  • disorientation
  • lapses in judgement
  • difficulty performing ADLs
  • difficulty performing mentally challenging tasks
  • misplacing things
  • apathy and loss of initiative
  • changes in mood
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11
Q

conditions that causes dementia

A

○ Alzheimer’s Disease
○ Vascular Pathology (e.g. multi-infarct dementia)
○ Lewy body dementia
○ Frontotemporal Lobar Degeneration
○ Parkinson’s Disease
○ Huntington’s Disease

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12
Q

Other causes of dementia that are least common:

A

● Wernicke-Korsakoff Syndrome secondary to Chronic
Alcohol Abuse
● Traumatic Brain Injury (TBI)
● Chronic Traumatic Encephalopathy due to repeated trauma
● Multiple Sclerosis
● Human Immunodeficiency Virus (HIV)

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12
Q

T or F

Alzheimer’s Disease is the most prevalent, followed by
Vascular Dementia and Mixed Dementia

A

True

13
Q

SD: Bilateral parietal and temporal lobes
(including hippocampus)

DP: Accumulation of neuritic plaques and neurofibrillary tangles

A

Alzheimer’s Disease

14
Q

SD: Frontal lobe degeneration and more temporal lobe atrophy than in Alzheimer’s disease

DP: Absence of plaquies; presence of tau protein (“Pick’s bodies”)

A

Pick’s Disease

15
Q

SD: Frontal and temporal lobes; basal ganglia

DP: Protein deposits (i.e., Lewy bodies”)

A

Lewy Body Disease

16
Q

SD: Bilateral cortical and/or subcortical atrophy

DP: Repeated blows to head; Neurofibrillary tangles and other microscopic material

A

Chronic traumatic encephalopathy (CTE)

17
Q

SD: Subcortical dementia; caudate nucleus of the basal ganglia

DP: Cell loss reducing the production of the neurotransmitter dopamine

A

Parkinson’s disease

18
Q

SD: Subcortical dementia; caudate nucleus of the basal ganglia

DP: Inherited atrophy of the caudate

A

Huntington’s disease

19
Q

SD: Any location

DP: Arteriosclerotic reductions of blood supply

A

Vascular Dementia

20
Q

SD: Medial temporal areas extending into orbitofrontal regions; usually bilateral

DP: Infection causing acute necrosis, edema, and hemorrhage

A

Herpes simplex viral encephalitis (HSVE)

21
Q

● Impairments of cortical functions appear early in cortical
dementia but not until the late stages of most subcortical
degenerative diseases.
● Motor impairments are prominent in the early stages.

A

Subcortical Dementia

22
Q

A degenerative disease affecting nuclei in the midbrain
and brain stem

A

PD

23
Q

● Is an inherited, degenerative neurologic disease
● Diagnostic markers:
○ chorea
○ cognitive decline
○ neurobehavioral symptoms

A

Huntington’s Disease

24
Q

a symptom that causes involuntary, irregular, or unpredictable muscle
movements so it affects the person’s arms, legs, and facial muscles.

A

chorea

25
Q

characterized by loss of neurons in the caudate nucleus and the putamen and patchy loss of cortical neurons in the frontal and temporal lobes, with occasional extension of neuron loss to the cerebellum

A

Huntington’s Disease

26
Q

● A rare disease
● Begins between the ages of 50 and 80
● Peak incidence in the early 60

A

Progressive Supranuclear Palsy (PSP)

27
Q

Possible CAUSES of PSP:

A

○ Unknown;
○ Viruses or slowly acting toxins;
○ Genetic

28
Q

Neuropathology of PSP

A

Caused by neuronal loss, neuronal abnormalities, and proliferation of glial cells throughout the brain stem and basal ganglia. Cortical neurons are largely spared.

29
Q

Early Symptoms of PSP

A

○ Paralysis of muscles responsible for downward gaze
○ Rigidity of neck muscles
○ Facial muscle weakness
○ Dysarthria

30
Q
A