Dementia

Question 1

Which dementia mainly has spherical cytoplasmic inclusions (eosinophilic, A-synuclein), also have ubiquitin

Answer 1

Dementia with Lewy Bodies

Question 2

Lewy Bodies where in Parkinson’s

Answer 2

Brainstem (also they have halo)

Question 3

Lewy Bodies where in Alzheimer’s

Answer 3

Amygdala

Question 4

Which disease has cytoplasmic inclusions (tau (Pick) +/- ubiquitin)

Answer 4

Pick’s disease

Question 5

Preserved letter fluency, poor category fluency is seen in what type of dementia

Answer 5

Semantic

Question 6

Which disease has tau deposition in brainstem, subthalamic nucleus, basal ganglia, cortices, vertical (downwards) palsy

Answer 6

Progressive supranuclear Palsy

Question 7

Alzheimer’s, Pick’s, PSP, corticobasal degeneration are all what

Answer 7

Tau-opathies

Question 8

Lewy Body Dementia, Parkinson’s disease and Multi System Atrophy are all what

Answer 8

Synucleopathies

Question 9

Papp-Lantos bodies (alpha-synuclein inclusions in oligodendrocytes found in the substantia nigra, cerebellum, and basal ganglia - found in what

Answer 9

Multi System Atrophy

Question 10

Parkinsonism, autonomic failure and cerebellar ataxia points towards what

Answer 10

Multi System Atrophy

Question 11

In MSA, what is it called if it presents mostly with autonomic features

Answer 11

Shy-Drager syndrome

Question 12

In MSA, what is it called if it presents mostly with parkinsonian symptoms

Answer 12

Striatonigral degeneration

Question 13

In MSA, what is it called if it presents mostly with cerebellar features

Answer 13

Olivopontocerebellar atrophy

Question 14

In MSA, there is greenish discolouration and atrophy of what

Answer 14

Putamen

Question 15

Dysbindin, Neuregulin, DISC-1, ZNF804A - genes in what

Answer 15

Schizophrenia

Question 16

Alpha-synuclein, LRRK2, PINK1 - genes in what

Answer 16

Lewy Body dementia

Question 17

MAPT - gene in what

Answer 17

Frontotemporal dementia

Question 18

In which dementia is visuospatial ability retained

Answer 18

Frontotemporal dementia

Question 19

In which dementia is insight, judgement and personality preserved

Answer 19

Vascular

Question 20

Which dementia leads to impaired odour identification

Answer 20

Alzheimer’s

Question 21

What is most common cause of REM sleep behaviour disorder

Answer 21

Alpha-synuclein pathology