Biotransformation

Question 1

Oxidation - which phase

Answer 1

1

Question 2

Reduction - which phase

Answer 2

1

Question 3

Hydrolysis - which phase

Answer 3

1

Question 4

Most common phase 1 reaction

Answer 4

Oxidation (with cytochrome P450 enzymes)

Question 5

Where are cytochrome P450 enzymes found

Answer 5

Endoplasmic reticulum of hepatocytes

Question 6

Which reactions yield polar, water-soluble, metabolite that is often still active

Answer 6

Phase 1

Question 7

Which phase reaction consist of adding hydrophilic groups to the original molecule, a toxic intermediate or a nontoxic metabolite

Answer 7

2

Question 8

Most common phase 2 reaction

Answer 8

Glucuronidation (conjugation with glucuronic acid)

Question 9

Methylation - which phase

Answer 9

2

Question 10

Acetylation - which phase

Answer 10

2

Question 11

Sulfation - which phase

Answer 11

2

Question 12

Conjugation with gluthianone - which phase

Answer 12

2

Question 13

Conjugation with amino acids (glycine, taurine, and glutamic acid) - which phase

Answer 13

2

Question 14

Which three amino acids can be part of conjugation reaction in phase 2

Answer 14

Glycine
Taurine
Glutamic acid

Question 15

Which phase reaction refers to the active transport of the compound into urinary or hepatobiliary system to facilitate elimination

Answer 15

3

Question 16

ATP-binding cassette (ABC) - which phase

Answer 16

3

Question 17

Solute carrier (SLC) transporters - which phase

Answer 17

3