Degradable polymer implants and inserts Flashcards
What type of system is Zoladex?
Biodegradable polymeric implant system
What drug is in Zoladex?
Goserelin - synthetic analogue of naturally occurring LHRH (luteinising hormone releasing hormone)
Indication of Zoladex
Prostate cancer
Uterine fibroids
Endometriosis
Describe the 1 month Zoladex implant
3.6mg of Goserelin
PLGA 50:50 copolymer
Describe the 3 month Zoladex implant
10.8mg Goserelin
Blend of high and low molecular weight lactide/glycolide copolymers (95:5)
What is the drug in Ozurdex?
Dexamethasone
Where is Ozurdex implanted?
Intravitreal implant
Injected into the eye (vitreous) and dissolved by vitreous gel
Indications of Ozurdex
Macular oedema
Non-infectious uveitis affecting the back segment of the eye
What polymers are in Ozurdex?
PLGA
What type of polymer is in Gliadel?
Polyanhydrides
Carboxyphenoxy propane: sebaic acid monomers
What is the ratio of Carboxyphenoxy propane: sebaic acid monomers in Gliadel?
20:80
How does increasing sebaic acid affect degradation rate in Gliadel?
increases degradation rate
How do you prepare Gliadel?
Dissolve drug and polyanhydride in solvent
spray dry - microspherical powder
compress into disk shaped wafer
How is drug released from Gliadel?
Surface erosion
How is biscarboxyphenoxy propane metabolised in the body?
Excreted in the urine
How is sebaic acid metabolised by the body?
Metabolised in the liver and expired as CO2 in the lungs
What drug is in Gliadel?
Carmustine
Indication of Gliadel
Brain cancer - glioblastoma multiforme
Are septopal chains degradable?
No
Drug in septopal chains
Gentamicin sulfate
Rifampicin is also common
Indication of septopal chains
Local delivery of antibiotic in treatment of musculoskeletal infections
what polymer is in Septopal chain
Non-resorbable polymethylmethacrylate
Drug in Septacin
Gentamicin
Polymers in Septacin
Sebaic acid and Erucic acid dimer
How are septacin chains made
melt polymerisation - SA and EAD mixed at 180 degrees celsius under vacuum
