Degenerative disease Flashcards
1
Q
What is Huntington’s disease
A
AD trinucleotide repeat neurodegenerative disorder
2
Q
Characteristics of Huntington’s disease
A
Chorea, incoordination, cognitive decline, personality changes, and psychiatric symptoms, culminating in immobility, mutism, and inanition
3
Q
Genetics of Huntington’s
A
known expansion of the CAG repeat length at the N-terminal end of the huntingtin gene