Degenerative disease Flashcards

1
Q

What is Huntington’s disease

A

AD trinucleotide repeat neurodegenerative disorder

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2
Q

Characteristics of Huntington’s disease

A

Chorea, incoordination, cognitive decline, personality changes, and psychiatric symptoms, culminating in immobility, mutism, and inanition

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3
Q

Genetics of Huntington’s

A

known expansion of the CAG repeat length at the N-terminal end of the huntingtin gene

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