deck_902536

Question 1

Regulation of Receptors - Private study, seems important

Answer 1

Definition of desensitisationDefinition of toleranceDefinition of supersensitivity Homologous vs Heterologous desensitisationBasic processes involved in desensitisation of GPCRs using B1 receptors as example(modification by phosphorylation, reversible receptor internalisation, down regulation)

Question 2

Define homologous desensitisation

Answer 2

A receptor decreases its response to a s-specific signalling molecule when that agonist is in high concentration

Question 3

Define heterologous desensitisation

Answer 3

Broad unresponsiveness to a variety of other agonists, after prolonged stimulation by one agonist

Question 4

Define tolerance

Answer 4

Reaction to a specific drug and concentration of the drug is progressively reduced, requiring an increase in concentration to achieve the desired effect

Question 5

Define super sensitivity

Answer 5

Reduced concentration of drug needed for same effect