deck_663353 Flashcards

1
Q

How do drugs exert effects in the body?

A

By binding to target receptors

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2
Q

Name the three biggest targets for drugs

A

EnzymesGPCRsIon channels

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3
Q

What are agonists?

A

Substances which mimick the actions of endogenous ligands and cause a response. Has both affinity and intrinsic efficacy.

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4
Q

What are anatgonists?

A

Substances which block endogenous ligands. Has affinity but NO intrinsic efficacy.

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5
Q

What is the concentration of drug molecules around receptors critical for?

A

The determination of drug action

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6
Q

What does MWt x Molarity equal?

A

g/L (mass)

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7
Q

What does g/L / MWt equal?

A

Molarity

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8
Q

What does g/l / M equal?

A

MWt

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9
Q

Why is it important to consider molarity?

A

Because drug molecules can be very different sizes, and so same mass can have vastly disproportional affects.

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10
Q

What is one of the most important factors in determining drug action?

A

The concentration of drug molecules around receptors is critical in determining drug action

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11
Q

Do drugs at equal molarity have proportional quantaties of drug molecules?

A

YES THEY DO SILLY

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12
Q

What is binding governed by?

A

By association and dissociation rates

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13
Q

What is the law of mass action related to?

A

It is related to the concentration of reactants and products.

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14
Q

How do we measure drug receptor interactions by binding?

A

By binding radioactively labelled ligands to cells OR membrans prepared from cells.

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15
Q

How many receptors is a large amount on a cell?

A

10,000 - 100,000

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16
Q

Page 37, page 4

A

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