deck_2464937 Flashcards
Old French name of pain?
peine
Latin name of pain?
poena, “punishment, penalty”
Greek name of pain?
Greek “ποινη” (poine), generally “price paid,” “penalty, ” “punishment.”
Unpleasant sensory and emotional experience associated with actual or potential tissue damage
PAIN
It is both a sensation and an emotion as it is accompanied by anxiety and the urge to escape or terminate the feeling.
PAIN
The ability to experience pain is essential for ??
protection from injury.
Insensitivity to pain is associated ?
with risk of tissue damage due to undiscovered injury.
The International Association for the Study of Pain advocates that
Relief from pain should be recognized as a human rightChronic pain should be considered a disease in its own rightPain medicine should have the full status of a specialty
fivers that transmit pain impulses?
A-delta (Aδ)and C fibers
fibers transmit light touch ?
A-beta (Aβ)
A peripheral nerve consists of the axons of three different types of neurons:
primary sensory afferents, motor neurons, and sympa- thetic postganglionic neurons
The cell bodies of pri- mary sensory afferents are located in the?
dorsal root ganglia in the vertebral foramina
primary afferent axon has two branches:
one projects centrally into the spinal cord and the other projects peripherally to innervate tissues
The largest-diameter afferent fibbers?
A-beta (Aβ),
respond maximally to light touch and/or moving stimuli; they are present primarily in nerves that innervate the skin
A-beta (Aβ),
In normal individuals, the activity of these fibers does not produce pain
A-beta (Aβ),
he small-diameter myelinated
A-delta (Aδ)
unmyelinated axons
(C fiber)
primary afferent nociceptors (pain receptors
(C fiber) , A-delta (Aδ)
is a non-associative learning process in which repeated administrations of a stimulus results in the progressive amplification of a response
Sensitization
Inflammatory mediators?
bradyki- nin, nerve-growth factor, some prostaglandins, and leukotrienes
Sensitization occurs at the level of the peripheral nerve terminal
(peripheral sen- sitization)
Sensitization at the level of the dorsal horn of the spinal cord
(central sensitization).
Peripheral sensitization occurs in?
damaged or inflamed tissues
generated by nociceptors during inflammation, enhances the excitability of nerve cells in the dorsal horn of the spinal cord
(central sensitization).
increased pain intensity in response to the same noxious stimulus; e.g. moderate pressure causes severe pain?
hyperalgesia
are normally relatively insensitive to nox- ious mechanical and thermal stimuli?
Viscera
Aδ and C fiber afferents innervating vis- cera are completely insensitive in normal , However, in the presence of inflammatory mediators, these afferents become sensitive to mechanical stimuli
silent nociceptors
It is a potent vasodilator, degranulates mast cells, is a chemoattractant for leukocytes, and increases the production and release of inflammatory mediators
substance P, an 11-amino-acid peptide
spinal neurons are most often activated by inputs from the?
skin
spatial displacement of pain sensation from the site of the injury that produces it is known as?
referred pain.
Five categories: Classification of Pain
Duration and severityAnatomical locationBody system involvedCauseTemporal characteristics
pain that is of recent onset and resolves quickly
Acute