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INTERNAL MEDICINE > CHAPTER 58: Bleeding and Thrombosis > Flashcards

CHAPTER 58: Bleeding and Thrombosis Flashcards

1
Q

I

A

Fibrinogen

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2
Q

II

A

Prothrombin

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3
Q

IIa

A

thrombin

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4
Q

III

A

Tissue thromboplastin

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5
Q

IV

A

Ionized calcium (Ca2+)

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6
Q

V

A

Proaccelerin

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7
Q

VII

A

Proconvertin

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8
Q

VIIa

A

Convertin

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9
Q

IX

A

Antihemophilic factor B; plasma thromboplastin component (PTC); Christmas factor

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10
Q

X

A

Stuart–Prower factor

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11
Q

XI

A

Plasma thromboplastin antecedent

PTA

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12
Q

XII

A

Hageman factor

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13
Q

XII

A

Fibrin-stabilizing factor (FSF)

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14
Q

Va

A

Accelerin

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15
Q

Prekallikrein

A

Fletcher factor

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16
Q

promote coagulation, called

A

procoagulants,

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17
Q

inhibit coagulation

A

anticoagulants

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18
Q

coagulants normally predominate, so that the blood does not coagulate while it is circulating in the blood vessels.

A

anticoagulants

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19
Q

formed continually by the liver, and it is continually being used throughout the body for blood clotting

A

Prothrombin

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20
Q

is required by the liver for normal for- mation of prothrombin as well as for formation of a few other clotting factors

A

Vitamin K

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21
Q

is a high-molecular-weight protein (MW = 340,000) that occurs in the plasma in quantities of 100 to 700 mg/dl. formed in the liver,

A

Fibrinogen

22
Q

is a protein enzyme with weak proteolytic capabilities. It acts on fibrinogen to remove four low-molecular- weight peptides from each molecule of fibrinogen

A

Thrombin

23
Q

activates the fibrin-stabilizing factor

A

Thrombin

24
Q

operates as an enzyme to cause covalent bonds between more and more of the fibrin monomer molecules, as well as multiple cross- linkages between adjacent fibrin fibers, thus adding tremendously to the three-dimensional strength of the fibrin meshwork.

A

fibrin-stabilizing factor XIII

25
Q

composed of a meshwork of fibrin fibers running in all directions and entrapping blood cells, platelets, and plasma

A

Blood Clot

26
Q

composed especially of phospholipids from the membranes of the tissue plus a lipoprotein complex that functions mainly as a proteolytic enzyme.

A

tissue thromboplastin Factor III

27
Q

activates factor VII to VIIa (intrinsic pathway)

A

Factor III

28
Q

activates factor X to Xa

A

Factor VIIa plus factor IV

29
Q

Factor Xa plus TF or FACTOR 3 plus Factor V is equals to?

A

prothrombin activator

30
Q

catalyses the cleaving of fibrinogen to fibrin?

A

thrombin

31
Q

prothrombin to IIa what complex catalyses?

A

prothrombin activator

32
Q

prevention of blood loss

A

HEMOSTASIS

33
Q

Procoagulant or Anticoagulant
• platelet adhesion and
aggregation

A

Procoagulant

34
Q

Procoagulant or Anticoagulant

• fibrin clot formation

A

Procoagulant

35
Q

Procoagulant or

• Prostacyclin, NO

A

Anticoagulant

36
Q

Procoagulant or Anticoagulant

• natural inhibitors of coagulation and fibrinolysis

A

Anticoagulant

37
Q

Procoagulant or Anticoagulant

• ectoADPase/CD39

A

Anticoagulant

38
Q

Procoagulant or Anticoagulant

• Heparan proteoglycans

A

Anticoagulant

39
Q

• Thrombomodulin

Procoagulant or Anticoagulant

A

Anticoagulant

40
Q

• Antithrombin

Procoagulant or Anticoagulant

A

Anticoagulant

41
Q

• Major plasma protease inhibitor of thrombin and other clotting factors in coagulation.

A

Antithrombin(Antithrombin III)

42
Q

• Neutralizes thrombin and the other activated coagulation factors by forming a complex bet the ACTIVE SITE of the enxyme and the REACTIVE CENTER of antithrombin.

A

Antithrombin(Antithrombin III)

43
Q

• Plasma glycoprotein that becomes anticoagulant when it is activated by thrombin that occurs on thrombomodulin

A

Protein C

44
Q

o transmembrane proteoglycan-binding site for thrombin on endothelial cell surfaces
• Cleaves and inactivate activated factors V and VIII

A

• Thrombomodulin

45
Q

o Cofactor which accelerates action of Protein C

A

• Protein S

46
Q

• Megakaryocyte

A

Platelets

47
Q
  • Megakaryocyte

* Normal Value:

A

150,000–450,000/L

48
Q

life span of platelets?

A

7 to 10days in circulation

49
Q

o Major regulator of platelet production
o synthesized in the liver
o ↑ synthesis within flammation

A

• Thrombopoietin (TPO)

50
Q
  • large multimeric protein present in both plasma and extracellular matrix of the subendothelial vessel wall - serves as the PRIMARY MOLECULAR GLUE
A

o Von Willebrand Factor

INTERNAL MEDICINE (3 decks)

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