Deck III Flashcards
Maternal blood types A and B antibodies are of what immunoglobulin class?
IgM.
Maternal blood type O antibodies are of what immunoglobulin class?
IgG.
Where do B cells aggregate in lymph nodes?
In germinal centres.
Where do T cells and dendritic cells primarily aggregate in lymph nodes?
In the paracortex.
What types of bacteria contain polysaccharide capsules which can be covalently bound to protein carriers and used as vaccine antigens?
Encapsulated bacteria.
Name four approved protein carriers that are used as vaccine antigens.
Mutant nontoxic diptheria toxin, Neisseria meningitidis outer membrane protein complex, and tetanus toxoid.
What is the pathophysiology associated with polymyositis?
Damage to myocytes with overexpression of MHC Class I proteins on the sarcolemma leads to infiltration with CD8+ T lymphocytes and myocyte damage.
Which cytokines preferentially promote B cell IgE production?
IL-4 and IL-13.
Which cytokine promotes eosinophil production?
IL-5.
Where do T-lymphocytes undergo positive selection?
Thymic cortex.
Where do T-lymphocytes undergo negative selection?
Thymic medulla
Describe the process of transmigration in inflammatory leukocyte accumulation.
Neutrophils migrate out of the vasculature by squeezing in between the cells via integrin attachments and adherence to platelet endothelial cell adhesion molecule I (PECAM-1) which is a protein found primarily at the peripheral intercellular junctions of endothelial cells.
What cell types are primarily responsible for clonal proliferation/ response to the EBV virus?
CD8+ lymphocytes.
Describe a CD8+ lymphocyte as seen on peripheral blood smear.
Cells much larger than quiescent lymphocytes with abundant cytoplasm, an eccentrically placed nucleus and a cell membrane that appears to conform to the borders of neighbouring cells.
Name the four seronegative spondyloarthropathies.
Ankylosing spondylosis, psoriatic arthritis, arthritis associated with IBD, and reactive arthritis.
