Death and Related Matters Flashcards
Is death a singular event or a process
It is a process
Involves brain death, cellular death etc.
One after the other
Is there a legal definition of death
No
Death is determined by your Dr
What if death is a process, how can time of death be recorded
For ToD recording, death is treated as a singular event
The doctor will record the approximate time - this becomes the official ToD
Usually the point they are deemed lifeless
What is taphophobia
The fear of being buried alive
What were safety coffins
Coffins built with safety features to ‘avoid’ being buried alive
Features include: ropes/levers connected to bells/flags, windows in coffins, hatches with keys, air tubes, trumpets etc.
Describe the history of premature burials
Many ‘genuine’ recorded cases in history - actually rare
Fear peaked during cholera epidemics in the 18th and 19th century
Usually only the upper classes that could afford safety measures like specialised coffins
Describe the German portable death chamber
Aimed to prevent premature burial Chamber with bell & window placed over empty grave
Watchman checked for signs of life or putrefaction over a few days
Floor opened into grave
Grave covered & filled
Chamber reused
Describe the Dr Taberger coffin design
Strings to head, hands & feet of corpse
Attached via tube to bell above ground
Any movement would raise alarm via the bell
Watchman used bellows & air tube before digging up
List the features of the Caselli safety coffin from the 90s
Alarm Intercom Torch Breathing apparatus Heart monitor & stimulator
For those with extreme fear - often have to be rich
List the stages of death
Apparent death (cardiac arrest, LOC) Brain death - sequential Somatic (clinical) death of person as a whole - this is what doctors 'diagnose' Cellular/molecular death Putrefaction
At which point during the death process is resuscitation possible
After apparent death - e.g. cardiac arrest or loss of consciousness
but before brain stem death (as this is irreversible)
Can sometimes resus after brain death begun if only the cortex is affected and stem is still alive - undesirable as will have no QoL
In which order do parts of the brain ‘die’ during the death process
First is the cerebral cortex - higher centers
Then the brain stem - this is the essential part
Then the whole brain dies - whole thing is hypoxic
What is the definition of resuscitation
Comes from latin - to raise again
To bring someone or something back to life or consciousness
To revive from unconscious.
Make active or vigorous again
List potential methods of cardio-pulmonary resuscitation (modern)
Mouth to Mouth Resuscitation
External cardiac massage (chest compression)- manual or now have machines that can do chest compressions
Defibrillation (electric shock)
Drugs (Adrenaline & Atropine)
Intubation & ventilation - helps with oxygenation
List some historical methods of resuscitation
Early - heat application or flagellation (whipping) - both provide stimuli
Bellows - similar to modern ventilation
Fumigation - smoke up rectum
Inversion - increase blood flow to brain
Rolling someone over a barrel - may compress chest and cause lung movement
Bury in snow - Russian method
Trotting horse method - again may cause cardiac massage
Mouth to mouth appeared in 50s
CPR - 70s
What is mean by apparent death
No or minimal signs of life, but responsive to prolonged resuscitation
In which situations are people often responsive to prolonged resuscitation
Electrocution - respiration paralyzed Drowning Overdose Hypothermia Children - brains are very resilient to hypoxia
Therefore resus may be attempted for longer in these scenarios
What are the clinical signs of death
Collapse with LoC & Muscle flaccidity (lost innervation)
Cessation of heartbeat (pulse)
Cessation of breathing
Dilated, fixed pupils - no response to light
What is involved in the clinical assessment of death
History & circumstances
Signs - e.g. cessation of pulse/breathing
Physical examination & auscultation - pulse, breath sounds etc.
Resuscitate if in doubt
If there is doubt that a patient is actually dead what should you do
Attempt resuscitation!
No harm in trying
What is included in the triad of Bichat for death confirmation
The failure of the body as an integrated system associated with irreversible loss of circulation, respiration and innervation
Loss of spontaneous heartbeat (circulation)
Irreversible loss of capacity to breathe (respiration)
Irreversible loss of consciousness (innervation)
Who can pronounce death
Usually has to be a doctor
In some cases a nurse can pronounce
Police are unable to even if obvious
When was the concept of brain stem death introduced
1959 - due to organ donation requirements
Needed organs but needed a way to determine the donors were ‘dead’
Describe the natural progression of a cardiac death
Starts with the disease or injury -e.g. atherosclerosis/thrombosis
1 - Primary cardiac arrest (e.g. due to infarction)
At this point CPR would be helpful
2 - Cerebral hypoxia
3 - Secondary respiratory arrest - caused by brain stem involvement
4 - Somatic (clinical) death
5 - Cellular death
How long does it take for the cerebral cortex to die from hypoxia
2-3 minutes
Damage is irreversible
How long does it take for the brain stem to die from hypoxia
Over 4 mins
Damage is irreversible
Whole brain will die at this point
Describe the natural progression of a respiratory death
Starts with the disease or injury - e.g. pneumonia, asthma, opiate overdose 1 - Primary respiratory arrest 2 - Cerebral hypoxia 3 - Secondary cardiac arrest 4 - Somatic (clinical) death 5 - Cellular death
List some of the causes of brain death
Cardiac arrest Any other Hypoxia Haemorrhage Stroke Poisoning Hypoglycaemia
Can destroy all or part of the brain
If you don’t want to do mouth to mouth, is cardiac massage enough
Yes
Mouth to mouth is still better but chest compression will suffice - may have some effect on lungs too
Definitely better than nothing!!
Some don’t want to do mouth to mouth due to infection risk etc
At which point would resuscitation not be successful
If brain death has already occurred
May survive if only the cortex is hypoxic but this will lead to very poor QoL
What are the functions of the cerebral cortex
Higher functions
Emotions
Sensation
Movement
Cortical death will lead to the loss of these functions
What are the functions of the brain stem
Consciousness -via the Reticular Activating System
Initiating respiration - via the respiratory centre
Control of BP and heart rate - via the vasomotor centre
All sensory input from whole body passes through BS to reach cortex (except smell & vision)
All motor output from cortex to body passes through BS
Mediates cranial nerve reflexes in the head and neck
Most vital part of the brain
If affected individually it can still be devastating even if rest of brain in intact
What is the necessary component of death
Brain stem death
Brain stem death is a bedside diagnosis - true or false
True
A doctor will look for the signs:
Loss of innervation, heartbeat and spontaneous respiration
What is medical death
Clinical pronouncement of death by a doctor
What is the closest we have to a legal definition of death
Brain stem death
If someone is in a persistent vegetative state, which parts of their brain are damaged and which are intact
Cortex has been damaged
So will have complete loss of cortical function - e.g. emotion, speech etc.
Brain stem is intact - still have spontaneous breathing, heartbeat etc
Describe a patient in a permanent vegetative state
They will be awake but unaware of self or environment
No speech or purposeful movement - loss of cortical function
Eyes will open/close cyclically and they can swallow, grimace
Will have spontaneous breathing & heartbeat
May live years with nutritional support
What can cause a persistent vegetative state
Anything that causes cortical damage but spares the brainstem
Cardiac arrest, hypoxia, trauma, poisoning, hypoglycaemia
How long must a persistent vegetative state last before it is diagnosed
Duration >6 (or 12) months
What is required for a diagnosis of persistent vegetative state
Obvious cause of brain damage No awareness of self or environment No reversible causes Duration >6 (or 12) months Must not respond to any part of the clinical assessment - details on another card
What is included in the assessment of a persistent vegetative state
No spontaneous or meaningful motor response, inc voice
No language comprehension or expression
No sustained, reproducible, purposeful or voluntary behavioural response to normal or noxious visual, auditory or tactile stimulus
Can you legally remove nutritional support from someone in a persistent vegetative state
Yes
Legal battle followed a victim of the Hillsborough disaster who was in a PVS and family/doctor granted right to withhold treatment
He died 9 days later
What happens if you remove nutritional support from someone in a persistent vegetative state
They will eventually die of dehydration and/or starvation
Cannot legally do anything to speed up the process as seen as murder
What is cortical atrophy
Shrinking of the brain cortex - reduced brain matter
Will also see dilation of the ventricles
Caused by long periods of inactivity or hypoxia such as persistent vegetative states
List the differences between a permanent vegetative state and brains stem death
Only cortex dead in PVS with BS intact whereas BS dead in BS death (cortex usually dead too unless localised BS lesion )
PVS patients will be awake but unaware whereas in BS death they are unconscious
PVS patients will be able to breathe spontaneously but BS death requires artificial ventilation
Both can have a spontaneous heartbeat - only in BS death if ventilated
Is there a moral dilemma in brain stem death
Not really
Legally not alive
You are basically ventilating a corpse - will not survive on their own
Removal of treatment is just allowing the death process to be completed
What can cause a primary brain stem death
Localised damage or lesion to the brain stem -e.g. brain stem haemorrhage
Do humans have any conscious control over their breathing
Yes
We can make ourselves breath more deeply or hold our breath
However, each breath is initiated spontaneously in the brain stem
Only so much control
Does the brain stem initiate our heat beats
NO
The heart beat is initiated spontaneously from within the heart -SA
Brain stem can just influence the rate
List the cranial nerves
- Olfactory (smell)
- Optic (sight)
- Oculomotor (eye movement)
- Trochlear (eye movement)
- Trigeminal (supplies sensation to face)
- Abducens (eye movement)
- Facial (motor nerve of face)
- Vestibulo-cochlear (hearing and balance)
- Glossophayngeal (muscular activity, swallowing etc.)
- Vagus (affect heart etc.)
- Accessory (shoulder movement)
- Hypoglossal (tongue movement)
Which cranial nerves can be tested at the bedside
CN 2-10
initiate their reflexes to test for brain stem function
How can you determine if a patient on ITU is actually dead
If the brain stem is irreversibly dead so are they
May appear alive due to artificial intervention
Ventilation maintained artificially
Heartbeat continues spontaneously - only due to ventilation
Feeding supported intravenously
Which medical staff can confirm brain stem death
Tests performed by 2 senior Drs
Must have been qualified for at least 5 years
Must be in an appropriate specialty
Tests are repeated at a later time to confirm
If both Drs are satisfied then brain stem death is confirmed and legal death is pronounced
What is the brain stem death UK code
Code of practice that govern the diagnosis of brain stem death in the UK
Allows it to be diagnosed at the bedside avoids controversy
Created by all medical colleges
Why is brain stem death an important concept
It’s introduction allowed organs to be taken from legally dead donors
Their organs are still being perfused so the organs are viable for transplantation
List some signs of brainstem activity (beyond the cranial nerve reflexes)
Epileptic fits - suggest cortical activity is reaching motor nerves
Decorticate rigidity
Dolls eye reflex - eyes remain fixed on moving head
All signs of life
What is required for the diagnosis of brain stem death
Specific pre-conditions and exclusion criteria must be met
Two sets of clinical tests are performed
Only when all confirmed can death be pronounced
Which preconditions must be met in order to confirm brain stem death
Deeply comatose, requiring artificial ventilation
Cause of coma is known - e.g. trauma, stroke
Reversible causes excluded
List reversible causes of coma that must be excluded in suspected brain stem death
Hypoxia
Hypotension
Space occupying lesion - haematoma, tumour
Drugs
Alcohol
Hypothermia
Metabolic conditions - diabetes, hypothyroidism
If treated brain stem function would return
List the tests used to elicit cranial nerve reflexes when confirming brain stem death
Pupils do not react to light (CN 2,3) No corneal reflex (3,5,7) No nystagmus upon ear irrigation (3,4,6,8) No grimace to pain (5,7) No gag reflex (9,10)
Describe the apnoea test
Patient is given
100% O2 for 10 min
then 5% CO2 for 5 min
Then they are disconnected from the ventilator for 10 min
This will result in rising CO2 in the blood stream which should stimulate spontaneous breathing if brain stem is still active
If brain stem dead, breathing will not restart
Cells all die at the same time after clinical death- true or false
False
Different cell types have different vulnerabilities to cessation of circulation