DD French Pharmacodynamics

Question 1

MC: The majority of drugs target a.) Nucleic acids b.) proteins c.) membrane lipids

Answer 1

C

Question 2

Define potency.

Answer 2

The concentration required to produce 50% of that individual drug?s Emax

Question 3

What is a drug?s most important determinant of clinical utility.

Answer 3

Efficacy

Question 4

What does the drug receptor theory assume?

Answer 4

1.) Interaction follows simple mass action relationships 2.) Drug binding is reversible 3.) Response is proportional to receptors occupied by drug

Question 5

T or F: At really high drug concentrations, adding more drug will get a proportional increase in drug response.

Answer 5

False. Generally, at bigh doses the drug response will level off as all the receptors are occupied. More drug will not get more effect if all receptors are occupied.

Question 6

What are full and partial agonists?

Answer 6

Full agonist - produces full or maximal response. Partial agonist - occupies the same number of receptors as a full agonist, but produces less of a response

Question 7

How would you overcome a reversible antagonist?

Answer 7

Increase the concentration of agonist

Question 8

What happens to the Emax of an agonist if its receptor is blocked by an irreversible antagonist.

Answer 8

Emax is reduced. Binding of an irreversible antagonist reduces the number of receptors to generate a response. Also an irreversible antagonist does not affect EC50.

Question 9

Physiological antagonists a.) directly block a receptor b.) binds to a drug and prevents its action c.) activates or blocks a response opposite of an agonist

Answer 9

C

Question 10

Chemical antagonists a.) directly block a receptor b.) binds to a drug and prevents its action c.) activates or blocks a response opposite of an agonist

Answer 10

B