DD French absorption Flashcards
T o F: The therapeutic window is the desired drug effect between the amount of drug required for a response and the amount of drug that causes problems.
TRUE
T or F: Onset of drug effect is characterized primarily as the absorption phase.
TRUE
T or F: Peak of drug effect is characterized primarily as the excretion phase.
FALSE. At peak affect some drug is probably still being absorbed, while some drug is being metabolized and excreted.
Name the 4 things that affect drug membrane passage.
1.) Drug size 2.) Lipid solubility 3.) Ionization 4.) Concentration gradient
T or F: It is hilarious when Dr. French says butt chugging.
TRUE. Its almost as funny as when Dr. Carry says scrotum.
What must a generic prove in order to go on the market?
Pharmaceutical equivalence and Bioequivalence - rate and extent of absorption are equal to brand name
Define bioequivalence according to the FDA.
Ratio of means and 90% confidence intervals of AUC and Cmax must be within 80-125% for Generic/Brand name
List the main factors affecting GI absorption (2 things).
1.) Extent of ionization and lipophilicity 2.) Gastric emptying time
T or F: Aerosolized drugs are most effective with a particle size of 10um or greater.
FALSE. Most effective is 1-5um particle size. Any smaller and the patient will exhale them. Any larger than 10 and the patient will get them stuck in their oropharynx.
Put these in the correct order from fastest route of absorption to slowest route of absorption: oral (not coated), transdermal, sublingual, inhalational
inhalational, sublingual, oral, transdermal
Put these in the correct order from fastest route of absorption to slowest route of absorption: intravenous, oral (not coated), intramuscular, subcutaneous (depot form)
intravenous, intramuscular, oral, subcutaneous
Describe rectal absorption.
Greater bioavailability than oral (50% goes to liver, 50% absorbed directly). Slow onset. Patient?s least favorite, probably.
