DA Pathways and Lesions - Neuro2 Flashcards
Name the 4 DA Pathways
- Mesocortical
- Mesolimbic
- Nigrostriatal
- Tuberoinfundibular
Blocking this pathway relieves/decreases positive symptoms of schizophrenia
Mesolimbic
Blocking this pathway causes Parkinson Dz
Nigrostriatal pathway
Blocking this pathway increases negative symptoms of schizophrenia
Mesocortical
From Ventral tegmental of Midbrain–> Limbic system
Mesolimbic
From Ventral tegmental of the Midbrain–> Cortex
Mesocortical pathway
Stimulation of this pathway can cause extra-pyramidal SEs
Nigrostriatal
2 Pathways blocked by neuroleptic schizophrenia drugs
Mesolimbic and Nigrostriatal
Anti-schizophrenic drugs target which pathway?
Mesolimbic
*DA antagonists
This pathway includes parts of the Basal Ganglia
Nigrostriatal
From Substantia nigra –> Neostriatum
Nigrostriatal pathway
From Arcuate nucleus of hypothalamus–> Pituitary
Tuberoinfundibular pathway
Blocking this pathway can cause social withdraw and depression
Mesocortical
*blocking increases neg. symptoms of schizophrenia
Dyskinesia and Acute Dystonia
Caused by meds that block (and thus upregulate receptors in) the Nigrostriatal pathway
Giving neuroleptic drugs to schizophrenics causes Parkinson symptoms by affecting which pathway?
Nigrostriatal
Blocking this pathway causes increased release of prolactin from Ant Pituitary
Tuberoinfundibular
Blocking this pathway via neuroleptic drugs can cause extrapyramidal SEs
Nigrostriatal
*Causes upregulation of DA receptors and thus extrapyramidal symptoms in schizophrenics
Blocking this pathway can cause hypogonadism
Tuberoinfundibular
*due to increased prolactin
Blocking this pathway can cause amennhorea in women and decreased libido in men. Also galactorrhea and gynecomastia.
Tuberoinfundibular
*due to increased prolactin
Anti-dopamine drugs can cause elevations in which hormone?
Prolactin
DA agonist used to Tx a prolactin secreting Ant Pituitary tumor
Bromocriptine
Anti DA drugs are also known as
Neuroleptics
