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DIT Cards > DA Pathways and Lesions - Neuro2 > Flashcards

DA Pathways and Lesions - Neuro2 Flashcards

1
Q

Name the 4 DA Pathways

A
  1. Mesocortical
  2. Mesolimbic
  3. Nigrostriatal
  4. Tuberoinfundibular
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2
Q

Blocking this pathway relieves/decreases positive symptoms of schizophrenia

A

Mesolimbic

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3
Q

Blocking this pathway causes Parkinson Dz

A

Nigrostriatal pathway

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4
Q

Blocking this pathway increases negative symptoms of schizophrenia

A

Mesocortical

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5
Q

From Ventral tegmental of Midbrain–> Limbic system

A

Mesolimbic

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6
Q

From Ventral tegmental of the Midbrain–> Cortex

A

Mesocortical pathway

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7
Q

Stimulation of this pathway can cause extra-pyramidal SEs

A

Nigrostriatal

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8
Q

2 Pathways blocked by neuroleptic schizophrenia drugs

A

Mesolimbic and Nigrostriatal

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9
Q

Anti-schizophrenic drugs target which pathway?

A

Mesolimbic

*DA antagonists

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10
Q

This pathway includes parts of the Basal Ganglia

A

Nigrostriatal

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11
Q

From Substantia nigra –> Neostriatum

A

Nigrostriatal pathway

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12
Q

From Arcuate nucleus of hypothalamus–> Pituitary

A

Tuberoinfundibular pathway

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13
Q

Blocking this pathway can cause social withdraw and depression

A

Mesocortical

*blocking increases neg. symptoms of schizophrenia

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14
Q

Dyskinesia and Acute Dystonia

A

Caused by meds that block (and thus upregulate receptors in) the Nigrostriatal pathway

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15
Q

Giving neuroleptic drugs to schizophrenics causes Parkinson symptoms by affecting which pathway?

A

Nigrostriatal

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16
Q

Blocking this pathway causes increased release of prolactin from Ant Pituitary

A

Tuberoinfundibular

17
Q

Blocking this pathway via neuroleptic drugs can cause extrapyramidal SEs

A

Nigrostriatal

*Causes upregulation of DA receptors and thus extrapyramidal symptoms in schizophrenics

18
Q

Blocking this pathway can cause hypogonadism

A

Tuberoinfundibular

*due to increased prolactin

19
Q

Blocking this pathway can cause amennhorea in women and decreased libido in men. Also galactorrhea and gynecomastia.

A

Tuberoinfundibular

*due to increased prolactin

20
Q

Anti-dopamine drugs can cause elevations in which hormone?

A

Prolactin

21
Q

DA agonist used to Tx a prolactin secreting Ant Pituitary tumor

A

Bromocriptine

22
Q

Anti DA drugs are also known as

A

Neuroleptics

DIT Cards (6 decks)

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