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Cell Bio > Cytoskeleton 1 + 2 > Flashcards

Cytoskeleton 1 + 2 Flashcards

exam 1

1
Q

size order of the filaments

A

microtubules> intermediate filaments> actin microfilaments

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2
Q

smallpox virus

A

variola

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3
Q

examples of pathogens that hijack the actin machinery of the host cell to propel themselves from one cell into another without being exposed to the immune system

A

smallpox virus, vaccinia virus and bacterium listeria

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4
Q

subunit of microtubules

A

tubulin

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5
Q

subunit of microfilaments

A

actin

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6
Q

subunit of intermediate filaments

A

lamins, keratin, desmin, neurofilaments, vimentin, GFAP

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7
Q

Acessory proteins of microtubules

A

Tau, MAPs

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8
Q

hyperstable structures of microtubules

A

axonemes (cilia and flagella) and centrioles

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9
Q

hyperstable structures of microfilaments

A

sarcomere (muscles) and microvilli

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10
Q

hyperstable structures of intermediate filaments

A

desmosome and hemi-desmosome

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11
Q

motors of microtubules

A

dynein (retrograde) and kinesin (orthograde)

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12
Q

motors of mycrofilaments

A

myosin

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13
Q

motors of intermediate filaments

A

none

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14
Q

funtion of microtubules

A

cilia/flagella functions, mitotic spindel, organelle transport

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15
Q

functions of microfilaments

A

phagocytosis, cytokinesis, cell motility, force generation (muscle), mebrane stabilization (RBC)

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16
Q

functions of intermediate filaments

A

mechanical integrity (nucleus, cell-cell, cell matrix)

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17
Q

Drugs of microtubules

A

taxol, vinca alkaloids (colchicine, vinblastine)

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18
Q

medical significance of microtubules

A

karatageners (primary Ciliary Dyskinesia, Immotile Cilia syndrome)
cancer chemotherapy dementias (Tau-opathies)

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19
Q

medical significance of microfilaments

A

listeria infection

smallpox/vaccinia

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20
Q

medical significance of intermediate filaments

A

laminopathies
blistering diseases
cancer diagnosis

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21
Q

Can you tell the size of fluorescence cells?

A

NO!

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22
Q

synapse to the cell bosy

A

retrogade

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23
Q

cell body to the synapse

A

orthograde

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24
Q

centrosomes are

A

microtubules based structures

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25
Q

replicate during the cell cycle and become the mitotic spindle apparatus

A

centrosomes

26
Q

true or false: microtubules can have different roles based on their structures

A

true

27
Q

triplet microtublues are _______ than double structure

A

stronger

28
Q

Cili microtubules order

A

cartwheel structure at the botto, a triplet mt to be a strong base, hollow mt space for cilia function, common mt formation for the rest.

29
Q

dynein fruntion

A

motor for mitotic spindle and retrogade transport

30
Q

Kartagener’s

A

Primary Ciliary dyskinesia

31
Q

Immotile Cilia syndrome

A

Kartagener’s/ microtubules dysfunction

32
Q

oocyte on drugs

A

taxol

33
Q

binds to microtubules and “freezes them”. They can not assemble and disassemble

A

Taxol

34
Q

prevent mt from assembling

A

colchine, vinblastine

35
Q

tau proteins attach to ______ and caps the end to stop them from growing

A

MT

36
Q

important to regulate the mt length

A

Tau

37
Q

stress fibers

A

actin

38
Q

localized only in cells at the migrating front

A

Beta actin

39
Q

actin seen in all cells

A

alpha actin

40
Q

Actin pairs with _______ to generate force in muscle cells

A

Myosin

41
Q

hyperstable actin structure

A

sarcomere

42
Q

cytokinesis is an ____ based process

A

actin based process

43
Q

Platelet Aggregation is

A

Actin-dependent

44
Q

Phagocytosis is an

A

actin-mediated process

45
Q

rapid actin assembly in phagocytosis causes

A

invagination

46
Q

microvilli

A

specialized actin structure

47
Q

smaller than cilia

A

microvilli

48
Q

microvilli functions

A

increases absorption, contains a terminal web for stability

49
Q

bacteria that uses the dark side of polymerization

A

listeria

50
Q

great model system for studying membrane-cytoskeleton interactions

A

erythocytosis

51
Q

hereditary spherocytosis

A

membrane-cytoskeleton interaction

52
Q

spleenomegaly

A

hereditary spherocytosis

53
Q

stereocilia

A

actin based

54
Q

not cell type specific, always present in cells

A

lamins

55
Q

muscle cells (smooth, striated, cardiac)

A

desmin

56
Q

neurons

A

neurofilamin

57
Q

epithelial cells

A

keratin

58
Q

glial cells (astrocytes)

A

glial fibrillary acidic protein (GFAP)

59
Q

many mesenchymal cells, including endothelial cells and fibroblasts

A

vimentin

60
Q

desmosomes are a type

A

of junction between cells

61
Q

anchors skin cells to the basal lamina

A

hemidesmosome

62
Q

epidermolysis bullosa

A

blistering disease

Cell Bio (10 decks)

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