Cytokins Flashcards
What is the cytokines in Regulators of innate immunity (Involved in natural immunity) (Proinflammatory) ?
TNF-alpha , IL-1, IL-6 , IL-8 , IL-12 , type 1 interferons
What is the cytokines in Regulators of adaptive immunity ?
CMIR : IL-2, TNF-beta , type 2 IFN
HMIR : IL-4 , IL-5 , IL-13
Inhibition of IR : IL-10 , THF-beta
What is the Stimulators of hematopoiesis ?
1- SCF
2- CSFs
3- IL-3 , IL-7
What is the is the principle cytokine that
mediates acute inflammation ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Acts on endothelial cells to stimulate
a st inflammation and coagulation ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Stimulates the liver to produce acute
phase proteins is ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Interacts with the hypothalamus to induce
fever (endogenous pyrogen) is ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Cachectic factor (muscle proteolysis and
fat catabolism) is the ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Interleukin-1 (IL-1) is Produced by ?
MO,macrophages, dendritic cells and a variety of
other cells
production by the macrophage
is stimulated by TNF and by the
presence of microbial products as
LPS (exogenous pyrogen) is ?
Interleukin-1 (IL-1)
It acts on the hypothalamus increasing
the body temperature causing fever
(endogenous pyrogen) is ?
IL-1
It acts on liver to induce production of
acute phase proteins is ?
IL-1
IL-1 and TNF-alpha is ?
Redundancy يعملون نفس الوظيفة
Initiation & Coordination of the IR ?
IL-1
IL-6 is stimulates the ?
stimulates the liver to produce acute
phase proteins.
Example of Alpha - chemokines ?
IL- 8 and eotaxins
Example of Beta- chemokines ?
RANTES and MCAF
What the cytokines that Principal mediator of early innate
immune responses to intracellular
microbes ?
Interleukin-12 (IL-12)