Cytokins Flashcards
What is the cytokines in Regulators of innate immunity (Involved in natural immunity) (Proinflammatory) ?
TNF-alpha , IL-1, IL-6 , IL-8 , IL-12 , type 1 interferons
What is the cytokines in Regulators of adaptive immunity ?
CMIR : IL-2, TNF-beta , type 2 IFN
HMIR : IL-4 , IL-5 , IL-13
Inhibition of IR : IL-10 , THF-beta
What is the Stimulators of hematopoiesis ?
1- SCF
2- CSFs
3- IL-3 , IL-7
What is the is the principle cytokine that
mediates acute inflammation ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Acts on endothelial cells to stimulate
a st inflammation and coagulation ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Stimulates the liver to produce acute
phase proteins is ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Interacts with the hypothalamus to induce
fever (endogenous pyrogen) is ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Cachectic factor (muscle proteolysis and
fat catabolism) is the ?
Tumor Necrosis Factor-alpha ( TNF-alpha )
Interleukin-1 (IL-1) is Produced by ?
MO,macrophages, dendritic cells and a variety of
other cells
production by the macrophage
is stimulated by TNF and by the
presence of microbial products as
LPS (exogenous pyrogen) is ?
Interleukin-1 (IL-1)
It acts on the hypothalamus increasing
the body temperature causing fever
(endogenous pyrogen) is ?
IL-1
It acts on liver to induce production of
acute phase proteins is ?
IL-1
IL-1 and TNF-alpha is ?
Redundancy يعملون نفس الوظيفة
Initiation & Coordination of the IR ?
IL-1
IL-6 is stimulates the ?
stimulates the liver to produce acute
phase proteins.
Example of Alpha - chemokines ?
IL- 8 and eotaxins
Example of Beta- chemokines ?
RANTES and MCAF
What the cytokines that Principal mediator of early innate
immune responses to intracellular
microbes ?
Interleukin-12 (IL-12)
What is the key inducer of CMI ?
Interleukin-12 (IL-12)
IFN-alpha (
Mononuclear phagocytes
IFN-beta. ( fibroblast IFN ) produced by ?
many cells, such as fibroblasts.
What is the function of Cytokines that Regulate Adaptive Immune Responses ?
proliferation and differentiation of B lymphocytes and T
lymphocytes
What is the growth factor for NK cells ?
Interleukin-2 (IL-2)
TH0 to TH1 by ?
IL-12
TH0 to TH2 by ?
IL-4
TH1 to TH2 by ?
IL-2
IL-4 is produced mainly by?
TH2 cells and mast cells.
What is a major stimulus for production
of IgE !
IL-4
What is the cytokines that isotype switching to IgE ?
IL-4
IL-13 is Produced primarily by ?
TH2 cells
Increases mucus production by lung
epithelial cells and may play a role in
asthma.
increase secretion in the airways is ?
IL-13
What is the cytokines that growth and activating factor
for eosinophils as a defense against helminths ?
IL-5
TH0 to TH17 by ?
IL-1 , IL-6 , IL -23
Intracellular pathogen ?
TH1
Extra cellular pathogen ?
TH2
Allergy and Asthma ?
TH2
Parasitic infection?
TH2
Promote innate mucosal immunity?
TH17
Fungal infection?
TH17
Extra cellular bacteria , Autoimmunity ?
TH 17
IL-17 deficiency leads to ?
mucocutaneous candidiasis.
Stem cell factor It is made mainly by ?
bone marrow stromal cells
acts on immature lymphoid progenitors is ?
IL-7
IL-3 supports the growth of ?
multi-lineage bone marrow stem cells
What is the Inhibitory Cytokines ?
IL-10 , Transforming growth factor-beta ( TGF-beta. )
