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Immunology - step > Cytokines/Chemokines > Flashcards

Cytokines/Chemokines Flashcards

1
Q

enhance activity of NK cells

A

IL-2-12 and IFNa-b

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2
Q

Il-2, Il-12, IFNa and IFNb

A

enhance activity of NK cells

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3
Q

cytokines secreted by TH1 cells

A

IFNy

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4
Q

cytokines secreted by TH2 cells

A

Il-4-5-10-13

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5
Q

inhibition of TH1 lineage

A

IL-4 and IL-10 from TH2 lineage

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6
Q

inhibition of TH2 lineage

A

IFNy from TH1 lineage

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7
Q

activation of TH1 lineage

A

IFNg and IL-12

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8
Q

activation of TH2 lineage

A

IL-4

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9
Q

stimulation of macrophages

A

IFNg from TH1

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10
Q

macrophages –> ? –> To –> TN1 –> ? –> macrophages

A

macrophages secreted IL-12 that stimulate To cells to differentiate into TH1 cells that secreted IFN to activated MO

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11
Q

cytokines produced by regulatory T cells

A

anti inflammatory
TGF beta
IL-10

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12
Q

Cytokines secreted by macrophages

A

IL-1-6-8-12 and TNFa

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13
Q

Describe IL-1

A

aka osteoclast-activating factor
causes fever, acute inflammation
activates endothelium to express adhesion molecules
induces chemokine secretion to recruite wbcs

from macrophages

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14
Q

Describe TNFa

A

mediates septic shock
activates endothelium
causes wbc recruitement and vascular leak

from macrophages

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15
Q

Describe IL-6

A

causes fever
stimulates production of acute-phase proteins

from macrophages

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16
Q

Describe IL-8

A

major chemotactic factor for PMNs

from macrophages

17
Q

Describe IL-12

A

induces To –> TH1
activates NK cells (also IL-2, IFna and IFNb)

from macrophatges

18
Q

Cytokines secreted by ALL T cells

A

IL-2, IL-3

19
Q

Describe IL-2

A

from all T cells

stimulates forwth of helper, cytotoxic and regulatory t cells as well as NK cells

20
Q

Describe IL-3

A

supports growth and differentiation of bone marrow stem cells
functions like GM-CSf

21
Q

Cytokiens from TH1 cells

A

IFNy

22
Q

Describe IFNy

A

secreted by NK cells in response to IL-12 from macrophages and TH1 cells

stimulates macrophages to kill phagocytosed pathogens
activates NK cells to kill virus-infected cells
increases MHC expression
increases antigen presentation by all cells

23
Q

list cytokines from TH2 cells

A

IL-4-5-10-13

24
Q

Describe IL-4

A

induces differentiation of TH2 cells
promotes growth of B cells
enhances clas switching to IgE and IgG

25
Q

Describe IL-5

A

promotes differentiation of B cells
enhances class switching to IgA
stimulates growth and differentiaton of eosionophils

26
Q

DEscribe IL-10

A

modulates inflammatory response
decreases expression of MHC I and TH1 cytokines
inhibits activated macropahges and dendritic cells

secreted by regulatory T cells (with TGFb) and TH2 cells

Immunology - step (7 decks)

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