Cytokines/Chemokines Flashcards
enhance activity of NK cells
IL-2-12 and IFNa-b
Il-2, Il-12, IFNa and IFNb
enhance activity of NK cells
cytokines secreted by TH1 cells
IFNy
cytokines secreted by TH2 cells
Il-4-5-10-13
inhibition of TH1 lineage
IL-4 and IL-10 from TH2 lineage
inhibition of TH2 lineage
IFNy from TH1 lineage
activation of TH1 lineage
IFNg and IL-12
activation of TH2 lineage
IL-4
stimulation of macrophages
IFNg from TH1
macrophages –> ? –> To –> TN1 –> ? –> macrophages
macrophages secreted IL-12 that stimulate To cells to differentiate into TH1 cells that secreted IFN to activated MO
cytokines produced by regulatory T cells
anti inflammatory
TGF beta
IL-10
Cytokines secreted by macrophages
IL-1-6-8-12 and TNFa
Describe IL-1
aka osteoclast-activating factor
causes fever, acute inflammation
activates endothelium to express adhesion molecules
induces chemokine secretion to recruite wbcs
from macrophages
Describe TNFa
mediates septic shock
activates endothelium
causes wbc recruitement and vascular leak
from macrophages
Describe IL-6
causes fever
stimulates production of acute-phase proteins
from macrophages
Describe IL-8
major chemotactic factor for PMNs
from macrophages
Describe IL-12
induces To –> TH1
activates NK cells (also IL-2, IFna and IFNb)
from macrophatges
Cytokines secreted by ALL T cells
IL-2, IL-3
Describe IL-2
from all T cells
stimulates forwth of helper, cytotoxic and regulatory t cells as well as NK cells
Describe IL-3
supports growth and differentiation of bone marrow stem cells
functions like GM-CSf
Cytokiens from TH1 cells
IFNy
Describe IFNy
secreted by NK cells in response to IL-12 from macrophages and TH1 cells
stimulates macrophages to kill phagocytosed pathogens
activates NK cells to kill virus-infected cells
increases MHC expression
increases antigen presentation by all cells
list cytokines from TH2 cells
IL-4-5-10-13
Describe IL-4
induces differentiation of TH2 cells
promotes growth of B cells
enhances clas switching to IgE and IgG
Describe IL-5
promotes differentiation of B cells
enhances class switching to IgA
stimulates growth and differentiaton of eosionophils
DEscribe IL-10
modulates inflammatory response
decreases expression of MHC I and TH1 cytokines
inhibits activated macropahges and dendritic cells
secreted by regulatory T cells (with TGFb) and TH2 cells