CYTOKINES AND INTERLEUKINS Flashcards
Interleukin 1 are released by ?
Macrophages
Interleukin 1 causes what?
Acute phase response
Fever
Hypotension
Tacycardia
Interleukin 2 role?
Released by TH cells
For growth and differentiation of T cells
IL3 role?
Released by activated Th1 cells
Differentiation and proliferation of myeloid progenitors
Interleukin 4
Released by macrophages and TH cells
Stimulates differentiation of B cells
Role of interleukin 8 ?
Released by macrophages
And Causes chemotaxis of neutrophils
Role of IL10
Produced by TH2
Inhibits TH1 cytokine - anti inflammatory cytokines
Role of IL12
Produced by dendritic cells
Macrophages and B cells
Stimulates differentiation of immature T cells into TH1 cells
Interferon gamma?
Released by Th1 cells and natural killer cells -ACTIVATES MACROPHAGES
Interferon beta produced by and action
produced by fibroblasts
antiviral action
Use of interferon B
reduces the frequency of exacerbations in patients with relapsing-remitting MS
Interferon alpha produced by and action?
produced by leucocytes
antiviral action
Interferon alpha use ?
useful in hepatitis B & C, Kaposi’s sarcoma, metastatic renal cell cancer, hairy cell leukaemia
Receptors for interferon ?
IFN-alpha and IFN-beta bind to type 1 receptors whilst IFN-gamma binds only to type 2 receptors.
interferon-alpha side effects ?
flu-like symptoms and depression