CYTOKINES AND INTERLEUKINS Flashcards

1
Q

Interleukin 1 are released by ?

A

Macrophages

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2
Q

Interleukin 1 causes what?

A

Acute phase response
Fever
Hypotension
Tacycardia

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3
Q

Interleukin 2 role?

A

Released by TH cells
For growth and differentiation of T cells

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4
Q

IL3 role?

A

Released by activated Th1 cells
Differentiation and proliferation of myeloid progenitors

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5
Q

Interleukin 4

A

Released by macrophages and TH cells

Stimulates differentiation of B cells

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6
Q

Role of interleukin 8 ?

A

Released by macrophages
And Causes chemotaxis of neutrophils

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7
Q

Role of IL10

A

Produced by TH2
Inhibits TH1 cytokine - anti inflammatory cytokines

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8
Q

Role of IL12

A

Produced by dendritic cells
Macrophages and B cells

Stimulates differentiation of immature T cells into TH1 cells

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9
Q

Interferon gamma?

A

Released by Th1 cells and natural killer cells -ACTIVATES MACROPHAGES

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10
Q

Interferon beta produced by and action

A

produced by fibroblasts
antiviral action

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11
Q

Use of interferon B

A

reduces the frequency of exacerbations in patients with relapsing-remitting MS

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12
Q

Interferon alpha produced by and action?

A

produced by leucocytes

antiviral action

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13
Q

Interferon alpha use ?

A

useful in hepatitis B & C, Kaposi’s sarcoma, metastatic renal cell cancer, hairy cell leukaemia

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14
Q

Receptors for interferon ?

A

IFN-alpha and IFN-beta bind to type 1 receptors whilst IFN-gamma binds only to type 2 receptors.

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15
Q

interferon-alpha side effects ?

A

flu-like symptoms and depression

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