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Immuno > Cytokines and Chemokines - Jerry- Part 3 > Flashcards

Cytokines and Chemokines - Jerry- Part 3 Flashcards

1
Q

Hematopoiesis - Role of B and T cell differentiation. Bone marrow and thymus

A

IL-7

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2
Q

Activate endothelial cells leading to de novo expression of: ICAM-1, VCAM-1, and E-selectin, and enhanced expression of ICAM-2. As well, they induce endothelial cells to secrete chemokines IL-8 and MCP-1.

A

IL-1 and TNF (synergistic)

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3
Q

promotes pCTL to CTL differentiation

A

IL-2

INF-gamma

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4
Q

Shifts Th0 response to Th2 phenotype

A

IL-4

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5
Q

Inhibitory molecule

A

IL-10

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6
Q

Plays a key role in fungal infections and in extracellular bacterial infections

A

IL-17

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7
Q

Chemotactic for eosinophils

A

IL-5

Eotaxin (CCL11)

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8
Q

recruiting eosinophils to tissues

A

IL-5

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9
Q

Act on hypothalamus to induce fever and play a key role in lowering of blood pressure leading to shock.

A

IL-1 & TNF (Sytematically)

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10
Q

Enhances NK cell cytotoxicity

A

IL-2

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Immuno (6 decks)

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