Cytokines and Chemokines - Jerry - Part 1 Flashcards
1
Q
Activate (or enhance activation of) macrophages to secrete cytokines (IL-1, 6, 12, TNF) & chemokines (IL-8 & MCP-1)
A
IL-1 and TNF (synergistic)
2
Q
Growth factor for T cells
A
IL-2
3
Q
Activates NK cells to secrete IFNγ (enhanced if either IL-15 or IL-18 is present)
A
IL-12
4
Q
Plays a role (along with IL-12) in inducing NK cells to secrete IFN-gamma
A
IL-15
IL-18
5
Q
upregulated in intestinal parasite infection
A
IL-33
6
Q
Down regulation of iNOS
A
IL-4
IL-10
TFG-beta (MOST EFFECTIVE!!)
7
Q
Hematopoiesis (General)
A
IL-3
IL-5
IL-7
Colony Stimulating Factors
8
Q
Activates iNOS
A
INF-gamma
TNF
9
Q
Elevated in multiple sclerosis, psoriasis, and Crohn’s disease
A
IL-23
10
Q
Inhibition of T cell proliferation
A
INF- alpha and INF-beta
