cytokines Flashcards
Neutrophil chemotactic factor
IL-8
IL-4 redundancy
IL-13
HIV gp120 antagonist
IL-16
promote megakaryocyte differentiation
IL-11
induce RORyt expression
IL-23
sustain memory CD8+T cell survival
IL-15，IL-7
induce M1 differentiation
IL-2, IFN-y
cachexin
TNF-a
promote Th0 → Th17
IL-6, TGF-b
promote class switching to IgG2a
IFN-y
Treg → Th17
IL-6,21,23, TGF-β
RORγt(need IL-23) , IRF4 , STAT3
Reference:Th0–> Th17 : IL-6 and TGF-b
Th17 → Treg
IL-2, RA(retinoicacid), IDO (indoleamine2,3-dioxygenase)
T-bet, FoxP3 , STAT5
CD22
co-inhibitory molecule of B cell
antibodies with extra constant domain
IgM / IgE
isotype with secretary component
IgM / IgA
only ab that mediates phagocytosis
IgG
IL-12
Th1 production
cell mediated cytotoxicity
macrophage
induce Th1 differentiation/NK
IFN-y producing cell
NK, Th1, CTL
TNF-a
neutrophil chemotactic factor
M1–> M2 differentialtion
IL-4, IL-10, -IL-13
IL-5
eosinophils promotion and differentiation / b cell / IgA
IL-17
neutrophil-mediated inflammation
IL-6
inflammatory, causing fever, B cell production
IL-2
signal 3, released by Th1, activating the whole world
IL-15
維持記憶型Tc cell數量、Th1小團體
IL12
殺殺殺！NK/Th1/CTL
redundant Th-18
IL-21
Enhance cytotoxic activity and IFN-γ production by activated NK and CD8+Tcells. / B cell
IL-17
released by T17, TGF-β & IL-6 (key factors) promote RORγt的表現 / neutrophil!!!!
Il-16
HIV的gp120 , chemokines for CD4 T, monocyte and eosinophil
Th1 cytokines
IL-2, IFN-y, TNF-b
Th2
IL-4, IL-5, IL-10
