cytokines Flashcards

1
Q

Neutrophil chemotactic factor

A

IL-8

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2
Q

IL-4 redundancy

A

IL-13

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3
Q

HIV gp120 antagonist

A

IL-16

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4
Q

promote megakaryocyte differentiation

A

IL-11

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5
Q

induce RORyt expression

A

IL-23

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6
Q

sustain memory CD8+T cell survival

A

IL-15,IL-7

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7
Q

induce M1 differentiation

A

IL-2, IFN-y

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8
Q

cachexin

A

TNF-a

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9
Q

promote Th0 → Th17

A

IL-6, TGF-b

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10
Q

promote class switching to IgG2a

A

IFN-y

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11
Q

Treg → Th17

A

IL-6,21,23, TGF-β
RORγt(need IL-23) , IRF4 , STAT3

Reference:Th0–> Th17 : IL-6 and TGF-b

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12
Q

Th17 → Treg

A

IL-2, RA(retinoicacid), IDO (indoleamine2,3-dioxygenase)

T-bet, FoxP3 , STAT5

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13
Q

CD22

A

co-inhibitory molecule of B cell

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14
Q

antibodies with extra constant domain

A

IgM / IgE

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15
Q

isotype with secretary component

A

IgM / IgA

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16
Q

only ab that mediates phagocytosis

A

IgG

17
Q

IL-12

A

Th1 production
cell mediated cytotoxicity
macrophage
induce Th1 differentiation/NK

18
Q

IFN-y producing cell

A

NK, Th1, CTL

19
Q

TNF-a

A

neutrophil chemotactic factor

20
Q

M1–> M2 differentialtion

A

IL-4, IL-10, -IL-13

21
Q

IL-5

A

eosinophils promotion and differentiation / b cell / IgA

22
Q

IL-17

A

neutrophil-mediated inflammation

23
Q

IL-6

A

inflammatory, causing fever, B cell production

24
Q

IL-2

A

signal 3, released by Th1, activating the whole world

25
Q

IL-15

A

維持記憶型Tc cell數量、Th1小團體

26
Q

IL12

A

殺殺殺!NK/Th1/CTL

redundant Th-18

27
Q

IL-21

A

 Enhance cytotoxic activity and IFN-γ production by activated NK and CD8+Tcells. / B cell

28
Q

IL-17

A

released by T17,  TGF-β & IL-6 (key factors) promote RORγt的表現 / neutrophil!!!!

29
Q

Il-16

A

HIV的gp120 , chemokines for CD4 T, monocyte and eosinophil

30
Q

Th1 cytokines

A

IL-2, IFN-y, TNF-b

31
Q

Th2

A

IL-4, IL-5, IL-10