Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology (Mine) > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What cells secrete Interleukin (IL)- 1 ?

A 
Monocytes
Macrophages
B cells
Dendritic cells
Endothelial cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does IL-1 do on Th cells?

A

Costimulates activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does IL-1 do on B cells?

A

Promotes maturation and clonal expansion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does IL-1 do on NK cells?

A

Enhances activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does IL-1 do on endothelial cells?

A

Increases expression of ICAMs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What does IL-1 do on macrophages and neutrophils?

A

Chemotactically attracts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does IL-1 do on hepatocytes?

A

Induces synthesis of acute phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does IL-1 do on hypothalamus?

A

Induces fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What cell secretes IL-2?

A

Th cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does IL-2 do on antigen-primed Th and CTLs?

A

Induces proliferation and enhances activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What cells secrete IL-3?

A

Th cells

NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does IL-3 do on hematopoietic cells (myeloid)?

A

Supports growth and differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What cells secrete IL-4?

A

Th2 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does IL-4 do on antigen-primed B cells?

A

Co-stimulates activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does IL-4 do on activated B cells?

A

Stimulates proliferation and differentiation and induces class switch to IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cells secrete IL-5?

A

Th2 and mast cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What does IL-5 do on bone marrow cells?

A

Induces eosinophil differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What cells secrete IL-6?

A 
Monocytes
Macrophages
Th2 cells
Bone marrow
Stromal cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What does IL-6 do on proliferating B cells?

A

Promotes terminal differentiation into plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What does IL-6 do on plasma cells?

A

Stimulates antibody secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What does IL-6 do on myeloid stem cells?

A

Helps promote differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What does IL-6 do on hepatocytes?

A

Induces synthesis of acute phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What cells secrete IL-7?

A

Bone marrow and Thymic stromal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What does IL-7 do on lymphoid stem cells?

A

Induces differentiation into progenitor B and T cells

25
Q

What cells secrete IL-8?

A

Macrophages and endothelial cells

26
Q

What does IL-8 do on neutrophils?

A

It is a chemokine. It induces adherence to endothelium and extravasation into tissues

27
Q

What cells secrete IL-10?

A

Th2 cells and Treg cells

28
Q

What does IL-10 do on macrophages?

A

Supresses cytokine production by Th1 cells

29
Q

What cells secrete IL-11?

A

Bone marrow stroma

30
Q

What does IL-11 do on bone marrow?

A

Increase platelet count

31
Q

What cells secrete IL-12?

A

Macrophages and B cells

32
Q

What does IL-12 do on activated CD8+ cells?

A

Acts synergistically with IL-2 to induce differentiation into CTLs

33
Q

What does IL-12 do on NK, LAK cells and activated Th1 cells?

A

Stimulates proliferation

34
Q

What cells secrete IL-13?

A

Th2 cell

35
Q

What does IL-13 do on B cells?

A

Induces isotype switch to IgE

36
Q

What cells secrete IL-17?

A

Th17 cells

37
Q

What does IL-17 do on fibroblasts, endothelial cells, and macrophages?

A

Increases inflammation

Attracts PMNs, induces IL-6, IL-1, TGF-beta, TNF-alpha and IL-8.

38
Q

What cells secrete IL-18?

A

Macrophages

39
Q

What does IL-18 do?

A

Acts on NK cells, Th cells and IFN-gamma synthesis

40
Q

What cells secrete interferon-alpha?

A

Leukocytes

41
Q

What does interferon-alpha do on uninfected cells?

A

Inhibits viral replication

42
Q

What cells secrete IL-22?

A

Th17

43
Q

What does IL-22 do on endothelium?

A

Stabilizes endothelial barrier and induces secretion of microbials

44
Q

What cells secrete interferon-beta?

A

Fibroblasts

45
Q

What does inferferon-beta do on uninfected cells?

A

Inhibits viral replication

46
Q

What cells secrete interferon-gamma?

A

Th1, CTLs and NK cells

47
Q

What does interferon-gamma do on macrophages?

A

Enhances activity

48
Q

What does interferon-gamma do many cells?

A

Increases expression of classes I and II MHC

49
Q

What does interferon-gamma proliferating B cells?

A

Induces class switch to IgG2a and blocks IL-4 induced class switch to IgE and IgG1

50
Q

What does interferon-gamma do on Th2 cells?

A

Inhibits proliferation

51
Q

What does interferon-gamma do on phagocytic cells?

A

Mediates effects important in DTH and treatment for CGD

52
Q

What cells secrete transforming growth factor-beta?

A

Platelets, macrophages, lymphocytes and mast cells

53
Q

What does transforming growth factor-beta do on proliferating B cells?

A

Induces class switch to IgA

54
Q

What cells secrete tumor necrosis factor-alpha?

A

Macrophages and NK cells

55
Q

What does tumor necrosis factor-alpha do on tumor cells?

A

Has cytotoxic effects

56
Q

What does tumor necrosis factor-alpha do on inflammatory cells?

A

Induces cytokine secretion and causes cachexia or chronic inflammation

57
Q

What cells secrete tumor necrosis factor-beta?

A

Th1 and CTL

58
Q

What does tumor necrosis factor-beta do on tumor cells?

A

Has cytotoxic and other effects like TNF-alpha

59
Q

What does tumor necrosis factor-beta do on macrophages and neutrophils?

A

Enhances phagocytic activity

Immunology (Mine) (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions